Allele Dmel\Dys^EP3397

General Information
Symbol	Dmel\Dys^EP3397	Species	D. melanogaster
Name		FlyBase ID	FBal0156626
Feature type	allele	Associated gene	Dmel\Dys

Map ( GBrowse )	Untitled Document
Allele class	amorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Christoforou et al., 2008)
Mutagen	P-element activity (FlyBase, 1996-)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:15,289,870..15,289,870 (FlyBase, 1996-, Christoforou et al., 2008, van der Plas et al., 2006, Shcherbata et al., 2007)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{EP}Dys^EP3397 is located 750bp upstream of the Dys 'dystrophin-like protein 2' isoform initiator ATG. (van der Plas et al., 2006)
Caused by insertion	P{EP}Dys^EP3397 (FlyBase, 1996-, Christoforou et al., 2008, van der Plas et al., 2006, Shcherbata et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class
	viable (with Df(3R)Exel6184) (Christoforou et al., 2008) visible (with Df(3R)Exel6184), with Scer\GAL4[-]: (Christoforou et al., 2008) visible (with Dys^det-1), with Scer\GAL4[-]: (Christoforou et al., 2008)
Phenotype Manifest In
	hemocyte \| pupal stage (with Df(3R)Exel6184) (Christoforou et al., 2008) posterior crossvein (with Df(3R)Exel6184), with Scer\GAL4[-]: (Christoforou et al., 2008) posterior crossvein (with Dys^det-1), with Scer\GAL4[-]: (Christoforou et al., 2008)
Detailed Description
	Statement Reference det¹/det^EP3397 transheterozygotes show a posterior crossvein phenotype with 100% penetrance. det^EP3397/Df(3R)Exel6184 transheterozygotes show a posterior crossvein phenotype with 100% penetrance. 4% of mutant wings have a "gapped" phenotype, 76% have a "detached" phenotype, 19% have a "point" phenotype and 1% are crossveinless. The number of hemocytes in the posterior crossvein region in det^EP3397/Df(3R)Exel6184 pupal wings is either greatly reduced compared to wild type or they are completely absent. (Christoforou et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference det^EP3397/Df(3R)ED5942 flies do not show the crossvein defect characteristic of det mutants, but show wing vein thickening. (Christoforou et al., 2008)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Dys^det-1 (Christoforou et al., 2008)
Comments
Stocks ( 1 )
Bloomington	17121 w¹¹¹⁸; P{EP}Dys^EP3397/TM6B, Tb¹
Notes on Origin
Discoverer

Comments
	Precise excision of the insertion in det^EP3397 reverts the mutant phenotype. (Christoforou et al., 2008)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	det³³⁹⁷ (Christoforou et al., 2008) det^EP3397 Dys^EP3397 (Christoforou et al., 2008, )
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Christoforou et al., 2008, Dev. Biol. 313(2): 519--532 The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins. [FBrf0203132] Shcherbata et al., 2007, EMBO J. 26(2): 481--493 Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. [FBrf0192541] van der Plas et al., 2006, J. Neurosci. 26(1): 333--344 Dystrophin is required for appropriate retrograde control of neurotransmitter release at the Drosophila neuromuscular junction. [FBrf0191057]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]

Allele Dmel\DysEP3397

Allele Dmel\Dys^EP3397