The fertility of Dcr-2L811fsX/Df(2R)BSC45 mutant males is severely reduced compared to wild-type controls (female fertility is not affected) due decreased number of mature sperm in their seminal vesicle. The spermatid nuclear alignment as well as the alignment of the investment cones in thee testes is disrupted.
Dcr-2L811fsX/Df(2R)BSC45 flies injected with Invertebrate Iridescent Virus type 6 (IIV-6) die earlier than IIV-6 infected wild-type controls. A fraction of Dcr-2L811fsX/Df(2R)BSC45 flies injected with buffer also die in the course of the experiment, indicating an increased sensitivity to stress associated with the mutation.
Dcr-2L811fsX mutant flies are more susceptible to non-virulent Flock house virus (FHV) mutant infection than wild-type. The FHV mutant that lacks viral protein FHV\B2, a known RNAi suppressor, is not pathogenic in wild-type flies, but Dcr-2L811fsX mutants show decreased survival after infection. Unlike the case in wild-type flies, the FHV FHV\B2 mutant replicates to high levels in Dcr-2L811fsX mutants.