One copy of Dcr-1^Q1147X increases the survival rates of both males and female adult flies subjected to nutrient starvation when compared to control flies. The levels of triacylglycerides (TAGs) and glycogen are increased at the beginning of starvation and the consumption of energy resources is delayed with time.

(Barrio et al., 2014)

Dcr-1^Q1147X mutants are embryonic lethal. Homozygous Dcr-1^Q1147X adult mushroom body clones display a reduction in cell number and absence of α'/β' and α/β neurons. Dcr-1^Q1147X adPN clones contain fewer cells than in wild-type cells- approximately 21 compared to 59 cells. This reduction is most likely due to premature adPN neuroblasts exit cell cycle during mid- to late larval stages, as cell number defects are not found in Scer\GAL4^GH146.PB>Avic\GFP^{S65T.Ubi-p63E.T:SV40\nls2}-labelled Dcr-1^Q1147X clones.

(Luhur et al., 2014)

7 days old females carrying homozygous germline clones result in egg chambers with 8 nurse cells and no oocyte with 37% penetrance.

(Azzam et al., 2012)

Flies homozygous for Dcr-1^Q1147X are not viable.

(Lawlor et al., 2012)

Dcr-1^19E2/Dcr-1^Q1147X and Dcr-1^18E6/Dcr-1^Q1147X results in pharate adults with normal morphology, although some adult escapers are seen.

(Smibert et al., 2011)

Wings containing homozygous clones are not flat and show blistering, but there is no loss of margin tissue. Small homozygous clones in the wing disc contain apoptotic cells.

(Bejarano et al., 2010)

Expression of Dcr-1^VDRC.cUa driven by Scer\GAL4^ple.PF in a heterozygous Dcr-1^Q1147X genetic background results in dopaminergic neuron loss and climbing defects.

(Gehrke et al., 2010)

Dcr-1^Q1147X heterozygosity enhances the wing size defects caused by the expression of Scer\GAL4^en-e16E>Dcr-1^GD11429. The viability of these flies is drastically reduced. Wing margin cells of Dcr-1^Q1147X mutant somatic clones display size defects compared to surrounding tissue. Wing disc clones of Dcr-1^Q1147X mutant cells are on average smaller than their corresponding wild-type twin clones. These clones are frequently fragmented and many clones are eliminated from the wing disc by 96 h after induction. Most Dcr-1^Q1147X mutant clones show signs of apoptosis. When mutant cells are given a relative growth advantage using the Minute technique using RpS3²/+ to impair growth of the other cells, Dcr-1^Q1147X mutant clones are recovered at the same frequency as wild-type control clones induced 96 h before dissection. However, Dcr-1^Q1147X mutant clones are much smaller than the wild-type control clones. Dcr-1^Q1147X mutant wing disc cells in somatic clones display G[[1]]-S cell cycle delay.

(Herranz et al., 2010)

Homozygous clones result in wing blistering, external loss of notum bristles and small, rough eyes. Homozygous clones contribute far less to the adult eye than their wild-type twin spots. Homozygous clones induced in the eye disc are unable to eliminate Minute heterozygous cells, in contrast to wild-type clones.

(Martin et al., 2009)

The low cell division index of homozygous female germline stem cell clones does not change under poor food conditions (in contrast to wild-type clones, where the cell division is dramatically reduced under poor food conditions).

(Yu et al., 2009)

Heterozygous females have normal ovary morphology and normal fertility.

(Kalidas et al., 2008)

Dcr-1^Q1147X MARCM clones do not exhibit a significantly reduced number of dendritic ends of ddaC neurons; however, terminal branches fail to elaborate properly.

(Xu et al., 2008)

Homozygous embryos do not develop past the first larval instar stage.

(Park et al., 2007)

Dcr-1^Q1147X mutant germline stem cells (GSCs) that have been generated during adult stages divide slowly compared to wild type, with mutant stem cells producing one progeny compared to 4 in controls. Dcr-1[Q1147X] mutant stem cells often leave the niche; if a wild type stem cell is also present in the niche it divides to replace the missing mutant, but if both of the GSCs present are mutant the niche is left empty. On average 12% of Dcr-1^Q1147X mutant GSCs are lost per day, compared to only 2% of control GSCs.

(Shcherbata et al., 2007)

Dcr-1^Q1147X mutants exhibit defects in eye morphology.

(Bilen et al., 2006)

Dcr-1^Q1147X flies show a modest but significant disruption of the heterochromatic silencing of the P{T1} reporter in line P{T1}T190-177 and of the P{T1(-FRT)} reporter in line P{T1(-FRT)}T190-177.

(Haynes et al., 2006)

70% of embryos produced by females with Dcr-1^Q1147X germline clones are devoid of pole cells and the remaining 32% contain ~16 pole cells. 37% of these embryos are arrested at embryonic cycle 1 or are unfertilized, and 9% are arrested before cycle 8. In addition, these embryos show severe defects in chromosomal segregation, nuclear distribution and supernumerary mitoses. Among mitotically normal embryos from Dcr-1^Q1147X mothers with nuclei present in the posterior pole region at cycle 9-14, 50% of them had no pole cells, and 22% contained fewer than ten pole cells.

(Megosh et al., 2006)

When Dcr-1^Q1147X germline clones are made in the ovarioles, many of the developmental stages are missing in the ovarioles. The proportion of germline stem cells (GSCs) remains close to normal in these clones. Mutant GSCs show normal spectrosome morphology and position. The frequency of cell division in mutant GSCs is reduced to 18% of normal levels. The number of these mutant GSCs that in S phase is also reduced, suggesting that the cell cycle is delayed at the G1/S transition. Affects in the cell cycle are also seen in male germline stem cells.

(Hatfield et al., 2005)

Dcr-1^Q1147X oocytes are ventralised.

(Nakahara et al., 2005)

Dcr-1^Q1147X has starvation stress response defective phenotype, suppressible by p53^-ns.3'/p53^-ns.5'

(Barrio et al., 2014)

Dcr-1^Q1147X has starvation stress response defective phenotype, suppressible by p53[+]/p53^-ns

(Barrio et al., 2014)

Dcr-1^Q1147X has increased cell death | somatic clone | third instar larval stage phenotype, suppressible by Myc^UAS.cZa/Scer\GAL4^αTub84B.PL

(Herranz et al., 2010)

Dcr-1^Q1147X, w^IR.GMR has eye color defective phenotype, suppressible by FBXO11^Q803R

(Lee et al., 2009)

Dcr-1^Q1147X has decreased occurrence of cell division | germline clone | oogenesis phenotype, suppressible | partially by dap[+]/dap⁴

(Hatfield et al., 2005)

Dcr-1^Q1147X is an enhancer of majority die during first instar larval stage phenotype of Gas41^f05565

(Gandhi et al., 2015)

Dcr-1^Q1147X is an enhancer of melanotic necrosis | adult stage phenotype of Gas41^f05565

(Gandhi et al., 2015)

Dcr-1^Q1147X/Dcr-1[+] is an enhancer of visible phenotype of Scer\GAL4^da.G32, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

(Lawlor et al., 2012)

Dcr-1^Q1147X is an enhancer of increased cell death phenotype of Hsap\ATXN3^{tr.Q61.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Dcr-1^Q1147X, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is an enhancer of increased cell death phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Dcr-1^Q1147X/Dcr-1[+] is a suppressor | partially of visible phenotype of Scer\GAL4^da.G32, Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Lawlor et al., 2012)

Dcr-1^Q1147X is a suppressor | partially | somatic clone of eye color defective phenotype of w^{miRNA.GUS.DsRed(T4)}

(Smibert et al., 2011)

Dcr-1^Q1147X is a suppressor | partially of eye color defective phenotype of w^IR.GMR

(Lee et al., 2009)

Dcr-1^Q1147X is a suppressor of neuroanatomy defective phenotype of Scer\GAL4⁴⁷⁷, mir-124^UAS.cXa

(Xu et al., 2008)

Dcr-1^Q1147X, w^IR.GMR has size defective phenotype

(Lee et al., 2009)

Dcr-1^Q1147X/Dcr-1[+], r2d2¹ has female sterile phenotype

(Kalidas et al., 2008)

Dcr-1^Q1147X/Dcr-1[+], Dcr-2^R416X has female fertile phenotype

(Kalidas et al., 2008)

Dcr-1^Q1147X, Mad¹²/Mad[+] has decreased cell number | somatic clone | larval stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X, Mad¹²/Mad[+] has decreased cell number | somatic clone | pupal stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X, Dcr-2^L811fsX has decreased cell number | somatic clone | larval stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X, Dcr-2^L811fsX has decreased cell number | somatic clone | pupal stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X/Dcr-1[+], Mad¹² has decreased cell number | somatic clone | larval stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X has wing disc | somatic clone | third instar larval stage phenotype, suppressible | partially by Myc^UAS.cZa/Scer\GAL4^αTub84B.PL

(Herranz et al., 2010)

Dcr-1^Q1147X, w^IR.GMR has eye phenotype, suppressible by FBXO11^Q803R

(Lee et al., 2009)

Dcr-1^Q1147X has germline stem cell | germline clone phenotype, suppressible | partially by dap[+]/dap⁴

(Hatfield et al., 2005)

Dcr-1^Q1147X has female germline cyst | germline clone | oogenesis phenotype, suppressible | partially by dap[+]/dap⁴

(Hatfield et al., 2005)

Dcr-1^Q1147X is an enhancer of scutum phenotype of Gas41^f05565

(Gandhi et al., 2015)

Dcr-1^Q1147X is an enhancer of scutellum phenotype of Gas41^f05565

(Gandhi et al., 2015)

Dcr-1^Q1147X/Dcr-1[+] is an enhancer of tergite phenotype of Scer\GAL4^da.G32, Zzzz\CAG^{99.UAS.Tag:MYC,Tag:FLAG}

(Lawlor et al., 2012)

Dcr-1^Q1147X/Dcr-1[+] is an enhancer of egg chamber phenotype of r2d2¹

(Kalidas et al., 2008)

Dcr-1^Q1147X, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Dcr-1^Q1147X, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is an enhancer of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Dcr-1^Q1147X is an enhancer of eye phenotype of Hsap\ATXN3^{tr.Q61.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Dcr-1^Q1147X is an enhancer of retina phenotype of Hsap\ATXN3^{tr.Q61.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Dcr-1^Q1147X/Dcr-1[+] is a suppressor | partially of tergite phenotype of Scer\GAL4^da.G32, Zzzz\CTG^{rCUG.99.UAS.Tag:MYC,Tag:FLAG}

(Lawlor et al., 2012)

Dcr-1^Q1147X is a suppressor | partially | somatic clone of eye phenotype of w^{miRNA.GUS.DsRed(T4)}

(Smibert et al., 2011)

Dcr-1^Q1147X is a suppressor | partially of eye phenotype of w^IR.GMR

(Lee et al., 2009)

Dcr-1^Q1147X/Dcr-1[+] is a suppressor of male germline cell phenotype of mael^M391/Df(3L)79E-F

(Pek et al., 2009)

Dcr-1^Q1147X is a suppressor of abdominal 1 dorsal multidendritic neuron ddaC phenotype of Scer\GAL4⁴⁷⁷, mir-124^UAS.cXa

(Xu et al., 2008)

Dcr-1^Q1147X is a suppressor of dendrite phenotype of Scer\GAL4⁴⁷⁷, mir-124^UAS.cXa

(Xu et al., 2008)

Dcr-1^Q1147X is a suppressor of eye phenotype of w^IR.GMR

(Lee et al., 2004)

Dcr-1^Q1147X is a suppressor of pigment cell phenotype of w^IR.GMR

(Lee et al., 2004)

Dcr-1^Q1147X, w^IR.GMR has eye phenotype

(Lee et al., 2009, Lee et al., 2004)

Dcr-1^Q1147X, Mad¹²/Mad[+] has female germline stem cell | somatic clone | larval stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X, Mad¹²/Mad[+] has female germline stem cell | somatic clone | pupal stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X, Dcr-2^L811fsX has female germline stem cell | somatic clone | larval stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X, Dcr-2^L811fsX has female germline stem cell | somatic clone | pupal stage phenotype

(Shcherbata et al., 2007)

Dcr-1^Q1147X/Dcr-1[+], Mad¹² has female germline stem cell | somatic clone | larval stage phenotype

(Shcherbata et al., 2007)

AGO1^k08121, Dcr-1^Q1147X has embryonic/first instar larval cuticle | segment polarity expression pattern phenotype

(Meyer et al., 2006)

Dcr-1^Q1147X, w^IR.GMR has interommatidial bristle phenotype

(Lee et al., 2004)

Dcr-1^Q1147X, w^IR.GMR has microchaeta phenotype

(Lee et al., 2004)

Dcr-1^Q1147X, w^IR.GMR has ommatidium phenotype

(Lee et al., 2004)