|Feature type||allele||Associated gene||Dmel\Dcp-1|
|Also Known As||Dcp-1Prev|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Dcp-1[Prev1] mutants display a significant delay of ~1hr in the rate of cell death, reaching the wild-type plateau level 4hrs after irradiation. Dcp-1[Prev1] mutants do not exhibit a difference in survival rate compared to wild-type controls.
Homozygous Dcp-1[Prev1] mutants are viable and do not display any defects in NMJ integrity or growth.
Dcp-1[Prev1] mutants exhibit an average of 9 vCrz somata at 7 hours after puparium formation, with no vCrz somata at 16 hours after puparium formation. The general morphology of vCrz neurons at 7 hours after puparium formation was comparable to those of wild-type at 4-5 hours after puparium formation, indicating that programmed cell death has been slowed down in the absence of Dcp-1 function.
Dcp-1[Prev1] mutants exhibit a mild reduction in dendritic branch pruning at 18 hours after puparium formation.
Developmental apoptosis is significantly reduced in homozygous third instar eye discs. γ-ray induced apoptosis is not suppressed in homozygous third instar wing discs.
Dcp-1Prev1 homozygotes are viable and fertile. The ovaries of these flies are largely normal, but have occasional egg chambers lacking follicle cells. This phenotype is exacerbated by nutrient deprivation to a much greater degree than in wild-type. Degeneration of egg chambers correlates with ectopic expression of cell-death markers.
|NOT suppressed by|
Dcp-1Prev1 is an enhancer | germline clone of decreased cell death | embryonic stage phenotype of Ice17
|NOT Suppressor of|
|Phenotype Manifest In|
Dcp-1[+]/Dcp-1Prev1 is a suppressor | partially of embryonic/larval neuromuscular junction phenotype of Ank2f02001
|NOT Suppressor of|
Dcp-1[Prev1]; Ice[Δ1] double mutants exhibit a block on cell death after irradiation. A Dcp-1[Prev1]; Ice[Δ1] double mutant background fails to abolish the ability of Ice[fl.5'3'UTR] mutants to induce cell death, although induction is at a reduced rate compared to in a Ice[Δ1] single mutant background.
Homozygous Dcp-1[Prev1] suppresses the NMJ degeneration seen in Ank2[f02001] mutants. One copy of Dcp-1[Prev1] is also able to partially suppress the phenotype.
Dcp-1[Prev1]; Nc[I29] double mutants exhibit an arrest of vCrz programmed cell death with all 16 vCrz neurons retained at 7 and 16 hours after puparium formation, compared to apoptosis of these neurons in wild-type controls.
Dcp-1[Prev1] ; Nc[I24]/Nc[I29] Ice[Δ1] triple mutant larvae undergo cell death with morphology similar to the midgut of wild-type animals when analysed from -4 to -1 hours relative to puparium formation.
Females containing Dcp-1[Prev1] Ice double mutant germline clones have persisting nurse cell nuclei in 21% of stage 14 egg chambers.
Developmental apoptosis in the eye disc is completely absent in Dcp-1[Prev1] ; Ice[Δ2C8] double homozygous third instar larvae. The reduction in adult eye size caused by expression of W[GMR.PG] is not suppressed if the eye is made homozygous for Dcp-1[Prev1] (using the eyFLP method).
The lethality of IceΔ1 is enhanced by Dcp-1Prev1: less than 1% of Dcp-1Prev1/+, IceΔ1/IceΔ1 animals eclose and Dcp-1Prev1/Dcp-1Prev1; IceΔ1/IceΔ1 animals die prior to, or during, early pupal stages. Almost all Dcp-1Prev1/Dcp-1Prev1; IceΔ1/IceΔ1 pupae arrest development prior to head inversion. Dcp-1Prev1/+, IceΔ1 flies show an increased number of lateral branches on the arista compared to IceΔ1 single mutant flies. Additionally, the genitalia misrotation phenotype of IceΔ1 flies is increased to full penetrance in Dcp-1Prev1/+, IceΔ1 flies.
Ice Dcp-1[Prev1] double mutant embryos derived from mutant female germline clones (so lacking maternal and zygotic function of Ice and Dcp-1 show significantly reduced levels of apoptosis compared to Ice single maternal and zygotic mutant embryos, containing only a few dying cells.
|Complementation & Rescue Data|
A Dcp-1[Prev1] heterozygous or homozygous background abolishes the ability of Dcp-1[Ice.5'3'UTR] mutants to induce cell death.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 7 )|
|Secondary FlyBase IDs|
|References ( 12 )|