FlyBase Allele Report: Dmel\Tspo[EY00814]

General Information

Symbol

Dmel\Tspo^EY00814

Species

D. melanogaster

Name

FlyBase ID

FBal0157107

Feature type

allele

Associated gene

Dmel\Tspo

Associated Insertion(s)

P{EPgy2}Tspo^EY00814

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Lin et al., 2014)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Tspo^EY00814

Cytology

Description

P-element insertion in the 3' regulatory region of Tspo.

(Lin et al., 2014)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:560,325..560,325 [-]

(Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lin et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response | male limited

(Lin et al., 2014)

chemical resistant

(Lin et al., 2014)

decreased cell death | conditional

(Lin et al., 2014)

long lived | male limited

(Lin et al., 2014)

radiation resistant

(Lin et al., 2014)

viable

(Lin et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Tspo^EY00814 flies are viable, grossly normal and have comparable developmental timing to wild type.

Tspo^EY00814 wing discs show a drastic suppression of cell death after gamma radiation, compared to controls. Similarly, cells isolated from Tspo^EY00814 3rd instar larval brains show significant suppression of apoptosis after exposure to H[[2]]O[[2]].

Male, but not female, Tspo^EY00814 flies show an extended lifespan over controls.

Male, but not female, Tspo^EY00814 flies show increased resistance to H[[2]]O[[2]] compared to controls. Sensitivity to starvation or heat stress in male and female Tspo^EY00814 flies is similar to controls.

(Lin et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tspo^EY00814/CG2789[+] is a suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Lin et al., 2014)

Tspo^EY00814/CG2789[+] is a suppressor of abnormal neuroanatomy phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Lin et al., 2014)

Tspo^EY00814/CG2789[+] is a suppressor of increased cell death phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Lin et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

15479

y¹ w^67c23; P{EPgy2}Tspo^EY00814

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG2789^EY00814

Tspo^EY00814

tspo^EY00814

(Lin et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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