Allele Dmel\Cerk^BG01100

General Information
Symbol	Dmel\Cerk^BG01100	Species	D. melanogaster
Name		FlyBase ID	FBal0157152
Feature type	allele	Associated gene	Dmel\Cerk

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (FlyBase, 1996-)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:1,193,320..1,193,320 (FlyBase, 1996-, Dasgupta et al., 2009, McElwain et al., 2011)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion in the predicted first intron. (McElwain et al., 2011) Insertion in the first intron. (Dasgupta et al., 2009)
Caused by insertion	P{GT1}Cerk^BG01100 (FlyBase, 1996-, Dasgupta et al., 2009, McElwain et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Stage 14-16 mutant embryos do not show an increase in mislocalisation of primordial germ cells compared to wild type. (McElwain et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Cerk[+]/Cerk^BG01100 is a suppressor of lethal \| maternal effect phenotype of Scer\GAL4^Act.PU, wntD^{Scer\UAS.P\T.cEa} (McElwain et al., 2011)
Phenotype Manifest In
Other
Statement Reference Cerk^BG01100, Mulk^LL03414 has germline cell \| maternal effect \| embryonic stage phenotype (McElwain et al., 2011, McElwain et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference One copy of Cerk[BG01100] suppresses the maternal effect lethality caused by expression of wntD[Scer\UAS.P\T.cEa] under the control of Scer\GAL4[Act.PU]. Maternal and zygotic double mutant Mulk[LL03414] ; Cerk[BG01100] embryos have an increased average number of mislocalised primordial germ cells compared to wild type at stages 14-16. This phenotype is not seen in either single mutant, or in Mulk[LL03414]/+ ; Cerk[BG01100] mutant embryos carrying a single paternally inherited copy of Mulk[+]. (McElwain et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	12454 w¹¹¹⁸; P{GT1}Cerk^BG01100
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Cerk^BG01100 Cerk^P{GT1} (McElwain et al., 2011) CG16708^BG01100 (Dasgupta et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	McElwain et al., 2011, PLoS ONE 6(11): e26993 A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. [FBrf0216663] Dasgupta et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(47): 20063--20068 Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. [FBrf0209371]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]

Allele Dmel\CerkBG01100

Allele Dmel\Cerk^BG01100