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General Information
Symbol
Dmel\Alk9
Species
D. melanogaster
Name
FlyBase ID
FBal0157356
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G16630449A

Amino acid change:

E1244K | Alk-PA; E1244K | Alk-PB

Reported amino acid change:

E1244K

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: E?K.

The E1244K mutation is within the conserved 'PTK' domain of the Alk protein.

Amino acid replacement: E1244K.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

axon & photoreceptor cell R8 | somatic clone

Detailed Description
Statement
Reference

Alk9 heterozygous pupae are normal in size.

R8 axons in mosaic adults with Alk9 in the lamina target neurons exhibit thickened terminals and fasciculate with R7/R8 axons in adjacent columns or fail to extend into the medulla neuropil.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Alk9 is a suppressor of small body | pupal stage phenotype of Nf1E2

Alk9/Alk[+] is a suppressor | partially of size defective | pupal stage phenotype of Nf1E2

Alk9/Alk[+] is a suppressor | partially of learning defective | adult stage phenotype of Nf1E2

Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The increase in mean number of boutons per neuromuscular junction which is seen in Nf1E2 third instar larvae is dominantly suppressed by Alk9.

One copy of Alk9 partially suppresses the small pupae phenotype seen in Nf1E2 homozygotes by increasing cell size. The Nf1E2 olfactory learning phenotype is also partially rescued.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Induced on: P{neoFRT}42D chromosome.

Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (7)