Allele Dmel\Alk⁹

General Information
Symbol	Dmel\Alk⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0157356
Feature type	allele	Associated gene	Dmel\Alk

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Loren et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:12,517,954..12,517,954 comment=Site of nucleic acid difference inferred by FlyBase based on reported amino acid change evidence=experimental na_change=G12517954A pr_change=E1244K\|Alk-PA reported_pr_change=E1244K (Loren et al., 2003, Englund et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: E?K. (Englund et al., 2003) The E1244K mutation is within the conserved 'PTK' domain of the Alk protein. (Loren et al., 2003) Amino acid replacement: E1244K. (Loren et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| somatic clone (Bazigou et al., 2007)
Phenotype Manifest In
	axon & photoreceptor cell R8 \| somatic clone (Bazigou et al., 2007)
Detailed Description
	Statement Reference Alk[9] heterozygous pupae are normal in size. (Gouzi et al., 2011) R8 axons in mosaic adults with Alk⁹ in the lamina target neurons exhibit thickened terminals and fasciculate with R7/R8 axons in adjacent columns or fail to extend into the medulla neuropil. (Bazigou et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Alk⁹/Alk[+] is a suppressor \| partially of learning defective \| adult stage phenotype of Nf1^E2 (Gouzi et al., 2011) Alk⁹/Alk[+] is a suppressor \| partially of size defective \| pupal stage phenotype of Nf1^E2 (Gouzi et al., 2011)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference One copy of Alk[9] partially suppresses the small pupae phenotype seen in Nf1[E2] homozygotes by increasing cell size. The Nf1[E2] olfactory learning phenotype is also partially rescued. (Gouzi et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Induced on: P{neoFRT}42D chromosome. (Loren et al., 2003) Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency. (Loren et al., 2003)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Alk⁹ (Bazigou et al., 2007, Loren et al., 2003, Bazigou et al., 2007, Gouzi et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Gouzi et al., 2011, PLoS Genet. 7(9): e1002281 The receptor tyrosine kinase alk controls neurofibromin functions in Drosophila growth and learning. [FBrf0216258] Bazigou et al., 2007, Cell 128(5): 961--975 Anterograde jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0192674] Englund et al., 2003, Nature 425(6957): 512--516 Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion. [FBrf0167923] Loren et al., 2003, EMBO Rep. 4(8): 781--786 A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. [FBrf0162095]
Supplementary material	Bazigou et al., 2007, Cell 128(5): Supplemental Data. Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0199314]

Allele Dmel\Alk9

Allele Dmel\Alk⁹