Allele Dmel\Alk⁸

General Information
Symbol	Dmel\Alk⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0157357
Feature type	allele	Associated gene	Dmel\Alk

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Loren et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:12,519,522..12,519,523 comment=Splice donor mutation resulting in truncation just after the transmembrane domain. evidence=experimental (Loren et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Encodes a protein truncated at the C-terminal end of the trans-membrane domain. (Englund et al., 2003) Carries a splice-donor site mutation that is predicted to generate a Alk protein that is truncated after the transmembrane domain. (Loren et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| somatic clone (Bazigou et al., 2007)
Phenotype Manifest In
	axon & photoreceptor cell R8 \| somatic clone (Bazigou et al., 2007)
Detailed Description
	Statement Reference The central nervous system of Alk[8] mutants appears morphologically normal in terms of segmental nerve branching and segmental muscle patterning. Neuropil synaptic differentiation appears normal in these mutants, with comparable labeling intensity, density and distribution of presynaptic and postsynaptic labels. Alk[8] mutant neuromuscular junctions appear correctly and stereotypically formed and elaborated, with no examples of muscle innervation failure or synaptic targeting errors. Mutant presynaptic active zones appear normally formed and with wild-type size. (Rohrbough and Broadie, 2010) R8 axons in mosaic adults with Alk⁸ in the lamina target neurons exhibit thickened terminals and fasciculate with R7/R8 axons in adjacent columns or fail to extend into the medulla neuropil. (Bazigou et al., 2007) Alk⁸/+ animals have no observable mutant phenotype. (Loren et al., 2003)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Induced on: P{neoFRT}42D chromosome. (Loren et al., 2003) Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency. (Loren et al., 2003)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Alk⁸ (Bazigou et al., 2007, Loren et al., 2003, Bazigou et al., 2007, Rohrbough and Broadie, 2010)
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Rohrbough and Broadie, 2010, Development 137(20): 3523--3533 Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. [FBrf0211915] Bazigou et al., 2007, Cell 128(5): 961--975 Anterograde jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0192674] Englund et al., 2003, Nature 425(6957): 512--516 Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion. [FBrf0167923] Loren et al., 2003, EMBO Rep. 4(8): 781--786 A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. [FBrf0162095]
Supplementary material	Bazigou et al., 2007, Cell 128(5): Supplemental Data. Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0199314]

Allele Dmel\Alk8

Allele Dmel\Alk⁸