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General Information
Symbol
Dmel\Alk10
Species
D. melanogaster
Name
FlyBase ID
FBal0157359
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G16630140A

Amino acid change:

D1347N | Alk-PA; D1347N | Alk-PB

Reported amino acid change:

D1347N

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: D?N.

The D1347N mutation is within the conserved 'PTK' domain of the Alk protein.

Amino acid replacement: D1347N.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The visceral mesoderm fails to fuse in stage 12 Alk10 mutant embryos and a number of mutant visceral mesoderm myoblasts migrate to the somatic mesoderm.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

Alk10 has visceral mesoderm phenotype, non-suppressible by Vrp1f06715

Alk10 has embryonic myoblast phenotype, non-suppressible by Vrp1f06715

Additional Comments
Genetic Interactions
Statement
Reference

Loss of Vrp1 through a Vrp1f06715 mutant background does not affect fusion in Alk10 mutants, as mutant cells of the visceral mesoderm are able to both migrate and fuse with cells of the somatic mesoderm.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Induced on: P{neoFRT}42D chromosome.

Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (7)