FB2025_01 , released February 20, 2025
Allele: Dmel\Alk10
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General Information
Symbol
Dmel\Alk10
Species
D. melanogaster
Name
FlyBase ID
FBal0157359
Feature type
allele
Associated gene
Dmel\Alk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Loren et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: D?N.

(Englund et al., 2003)

The D1347N mutation is within the conserved 'PTK' domain of the Alk protein.

(Loren et al., 2003)

Amino acid replacement: D1347N.

(Loren et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,630,140..16,630,140 [-]
Nucleotide change:

G16630140A

Amino acid change:

D1347N | Alk-PA; D1347N | Alk-PB

Reported amino acid change:

D1347N

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

(Englund et al., 2003, Loren et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The visceral mesoderm fails to fuse in stage 12 Alk10 mutant embryos and a number of mutant visceral mesoderm myoblasts migrate to the somatic mesoderm.

      (Eriksson et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Alk10 has visceral trunk mesoderm phenotype, non-suppressible by Vrp1f06715

      (Eriksson et al., 2010)

      Alk10 has embryonic myoblast phenotype, non-suppressible by Vrp1f06715

      (Eriksson et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Loss of Vrp1 through a Vrp1f06715 mutant background does not affect fusion in Alk10 mutants, as mutant cells of the visceral mesoderm are able to both migrate and fuse with cells of the somatic mesoderm.

      (Eriksson et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: P{neoFRT}42D chromosome.

      (Loren et al., 2003)

      Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency.

      (Loren et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)