FlyBase Allele Report: Dmel\Akt[UAS.Exel]

General Information

Symbol

Dmel\Akt^UAS.Exel

Species

D. melanogaster

Name

FlyBase ID

FBal0157364

Feature type

allele

Associated gene

Dmel\Akt

Associated Insertion(s)

Carried in Construct

P{UAS-Akt.Exel}

Also Known As

UAS-AKT, UAS-AKT1, P{UAS-Akt1.Exel}, UAS-Akt1.Exel, UAS-dAkt, UAS-Akt-WT

Key Links

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-Akt.Exel}

Cytology

Description

Wild type sequences for the short, 60 kD form of Akt1 have been cloned into P{Express-UAS} where their expression is governed by UAS regulatory sequences.

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Akt

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of alcohol use disorder

CEA

(Eddison et al., 2011)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Liévens et al., 2008)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-PR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

ameliorates cancer

modeled by Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Akt1^{Scer\UAS.Exel} rescues some aspects of the Hsap\HTT^{Q93.ex1p.Scer\UAS} Huntington's disease model but not others: the retinal toxicity and locomotor performance defects are significantly ameliorated, but the brain neuronal death and reduced lifespan are unaffected.

(Liévens et al., 2008)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Parrish et al., 2009)

abnormal size, with Scer\GAL4^GMR.long

(Das et al., 2014)

chemical sensitive, with Scer\GAL4^elav-C155

(Eddison et al., 2011)

increased cell size, with Scer\GAL4^en-e16E

(Puseenam et al., 2009)

increased cell size, with Scer\GAL4^ppl.PP

(Das et al., 2014)

lethal | heat sensitive, with Scer\GAL4^Mef2.PR

(Das et al., 2014)

visible, with Scer\GAL4^ap-md544

(Das et al., 2014, Lee et al., 2010)

visible, with Scer\GAL4^Bx-MS1096

(Cliffe et al., 2009)

Phenotype Manifest In

adult head, with Scer\GAL4^GMR.long

(Das et al., 2014)

dendrite | larval stage, with Scer\GAL4^ppk.PG

(Parrish et al., 2009)

embryonic/larval fat body, with Scer\GAL4^ppl.PP

(Das et al., 2014)

embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PU

(Ibar et al., 2013)

eye, with Scer\GAL4^GMR.long

(Funakoshi et al., 2011)

larval muscle system, with Scer\GAL4^Mef2.PR

(Das et al., 2014)

wing, with Scer\GAL4^ap-md544

(Das et al., 2014)

wing, with Scer\GAL4^Bx-MS1096

(Cliffe et al., 2009)

wing | posterior, with Scer\GAL4^en-e16E

(Puseenam et al., 2009)

wing blade, with Scer\GAL4^ap-md544

(Lee et al., 2010)

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PU

(Ibar et al., 2013)

Detailed Description

Statement

Reference

There is no increase in the frequency of clone splitting when Akt1^{Scer\UAS.Exel}-expressing clones are generated in wild type tissues compared with wild type clones in wild type tissue.

(Levayer et al., 2015)

Expression of Akt1^{Scer\UAS.Exel} in the eye and head under the control of Scer\GAL4^GMR.long results in an increase in head size compared with controls.

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^Mef2.PR results in an increase in the breadth of larval muscle fibres.

Expression of Akt1^{Scer\UAS.Exel} in the fat body under the control of Scer\GAL4^ppl.PP results in an increase in cell and nucleus size.

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^ap-md544 causes the wing to bend downward.

(Das et al., 2014)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal shrinkage and disappearance of pupal neuroblasts.

(Homem et al., 2014)

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^ple.PF or Scer\GAL4^elav.PU leads to an increase in survival duration by about 5-7 days when exposed to 0.5ppm 1-octen-3-ol.

(Inamdar et al., 2014)

Expression of Akt1^{Scer\UAS.Exel} in the eye, under the control of Scer\GAL4^GMR.PF, does not result in a visible phenotype.

(Nandi et al., 2014)

Clones expressing Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^Act5C.PU in the third larval instar wing disc and fat body are larger than control clones.

(Ibar et al., 2013)

Axon regeneration of class IV da neurons in the ventral nerve cord (after axon severing at the commissure junction at 48 hours after egg laying) is enhanced in larvae expressing Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^ppk.PG compared to wild type controls.

The dendrites of ddaC neurons of larvae expressing Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^ppk.PG show enhanced regeneration (after dendrite severing at 48 hours after egg laying) compared to wild-type controls. No substantial dendrite regeneration is seen in the mutant larvae after dendrite severing at 72 hours after egg laying.

(Song et al., 2012)

Neuronal expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^elav-C155 increases sensitivity to ethanol sedation.

Neuronal expression of Akt1^{Scer\UAS.Exel} (under the control of Scer\GAL4^elav-C155) throughout development (until eclosion of the adult fly, when Scer\GAL80^ts.αTub84B is induced) results in increased ethanol sensitivity. The converse experiment, with over-expression in neurons only after eclosion, does not alter ethanol sensitivity.

(Eddison et al., 2011)

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^fat results in increased lipid levels compared to controls.

(Wang et al., 2011)

Expression of Akt1^{Scer\UAS.Exel} driven by Scer\GAL4^ap-md544 in dorsal cells of the wing causes an overgrowth phenotype in which the wing bends downward.

(Lee et al., 2010)

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^Bx-MS1096 results in a down-curled wing phenotype in 53.2% of flies.

(Cliffe et al., 2009)

Ectopic expression of Akt1^{Scer\UAS.Exel}-driven by Scer\GAL4^ppk.PG causes a significant increase in dendrite coverage of larval hemisegments.

(Parrish et al., 2009)

Overexpression of Akt1^{Scer\UAS.Exel} using Scer\GAL4^en-e16E enlarges the posterior wing compartment area and increases cell size.

(Puseenam et al., 2009)

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^GMR.PU has no effect on the external appearance of the eye. The number of photoreceptors per ommatidium is similar to wild type.

Expression of Akt1^{Scer\UAS.Exel} has no effect on lifespan when expressed under the control of any of Scer\GAL4^elav-C155, Scer\GAL4^repo.PU or Scer\GAL4^Eaat1.PR.

(Liévens et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Akt^UAS.Exel, Scer\GAL4^ap-md544 has visible phenotype, enhanceable by Df(2R)Sesn-8A11/Df(2R)Sesn-8A11

(Lee et al., 2010)

Suppressed by

Statement

Reference

Akt^UAS.Exel, Scer\GAL4^GMR.long has abnormal size phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^GMR.long

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^Mef2.PR has lethal | heat sensitive phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^Mef2.PR

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^ap-md544 has visible phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^ap-md544

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^ap-md544 has visible phenotype, suppressible by Sesn^d04539, Scer\GAL4^ap-md544

(Lee et al., 2010)

Akt^UAS.Exel, Scer\GAL4^en-e16E has increased cell size phenotype, suppressible by Girdin^RNAi.UAS, Scer\GAL4^en-e16E

(Puseenam et al., 2009)

Enhancer of

Statement

Reference

Akt^UAS.Exel, Scer\GAL4^NP0001 is an enhancer of increased cell size phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Akt^UAS.Exel, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Acn^{UAS.cNa.Tag:MYC}, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^Mhc.PK/Akt^UAS.Exel is a suppressor | partially of atrophy | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Exel, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU

(Chuang et al., 2014)

Akt^UAS.Exel, Scer\GAL4^e16A is a suppressor of increased cell size phenotype of Scer\GAL4^e16A, trbl^UAS.Tag:FLAG

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^e16A is a suppressor of visible phenotype of Scer\GAL4^e16A, trbl^UAS.Tag:FLAG

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^ppl.PP is a suppressor of decreased cell size phenotype of Cds^NIG.7962R, Scer\GAL4^ppl.PP

(Liu et al., 2014)

Akt^UAS.Exel, Scer\GAL4^repo.PU is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^elav-C155 is a suppressor of decreased cell number phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^GMR.PU is a suppressor of abnormal eye color | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

NOT Suppressor of

Statement

Reference

Akt^UAS.Exel/Scer\GAL4^r4 is a non-suppressor of atrophy | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Exel/Scer\GAL4^ppk.PG is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of path^dg50/Df(3L)BSC773

(Lin et al., 2015)

Akt^UAS.Exel, Scer\GAL4^salm.EPv is a non-suppressor of visible phenotype of Scer\GAL4^salm.EPv, Tcs5^RNAi.UAS.462

(Ibar et al., 2013)

Akt^UAS.Exel, Scer\GAL4^Hml.Δ is a non-suppressor of increased cell number | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Akt^UAS.Exel, Scer\GAL4^elav-C155 is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^elav-C155 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^elav-C155 is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^repo.PU is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^Eaat1.PR is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Liévens et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Akt^UAS.Exel, Scer\GAL4^ap-md544 has wing blade phenotype, enhanceable by Df(2R)Sesn-8A11/Df(2R)Sesn-8A11

(Lee et al., 2010)

Suppressed by

Statement

Reference

Akt^UAS.Exel, Scer\GAL4^GMR.long has adult head phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^GMR.long

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^Mef2.PR has larval muscle system phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^Mef2.PR

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^ppl.PP has embryonic/larval fat body phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^ppl.PP

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^ap-md544 has wing phenotype, suppressible by trbl^UAS.Tag:FLAG, Scer\GAL4^ap-md544

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^GMR.long has eye phenotype, suppressible by wdb^GS9548, Scer\GAL4^GMR.long

(Funakoshi et al., 2011)

Akt^UAS.Exel, Scer\GAL4^ap-md544 has wing blade phenotype, suppressible by Sesn^d04539, Scer\GAL4^ap-md544

(Lee et al., 2010)

Akt^UAS.Exel, Scer\GAL4^en-e16E has wing | posterior phenotype, suppressible by Girdin^RNAi.UAS, Scer\GAL4^en-e16E

(Puseenam et al., 2009)

Enhancer of

Statement

Reference

Scer\GAL4^Mhc.PK/Akt^UAS.Exel is an enhancer of extracellular matrix | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Exel, Scer\GAL4^NP0001 is an enhancer of adult midgut epithelium phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Akt^UAS.Exel, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Acn^UAS.cNa, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Akt^UAS.Exel, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Acn^{UAS.cNa.Tag:MYC}, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Suppressor of

Statement

Reference

Akt^UAS.Exel/Scer\GAL4^r4 is a suppressor | partially of larval muscle system | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Scer\GAL4^Mhc.PK/Akt^UAS.Exel is a suppressor | partially of A1-7 ventral longitudinal muscle 3 | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Exel/Scer\GAL4^r4 is a suppressor | partially of muscle attachment site | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Scer\GAL4^Mhc.PK/Akt^UAS.Exel is a suppressor | partially of muscle attachment site | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Exel/Scer\GAL4^Lsp2.PH is a suppressor of phenotype of CycG^HR7

(Fischer et al., 2015)

Akt^UAS.Exel/Scer\GAL4^Lsp2.PH is a suppressor of embryonic/larval oenocyte | larval stage phenotype of CycG^HR7

(Fischer et al., 2015)

Akt^UAS.Exel, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU

(Chuang et al., 2014)

Akt^UAS.Exel, Scer\GAL4^GMR.PU is a suppressor of ommatidium phenotype of Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU

(Chuang et al., 2014)

Akt^UAS.Exel, Scer\GAL4^e16A is a suppressor of wing phenotype of Scer\GAL4^e16A, trbl^UAS.Tag:FLAG

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^e16A is a suppressor of wing hair phenotype of Scer\GAL4^e16A, trbl^UAS.Tag:FLAG

(Das et al., 2014)

Akt^UAS.Exel, Scer\GAL4^elav-C155 is a suppressor of photoreceptor phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Akt^UAS.Exel, Scer\GAL4^GMR.PU is a suppressor of eye | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Liévens et al., 2008)

NOT Suppressor of

Statement

Reference

Akt^UAS.Exel/Scer\GAL4^r4 is a non-suppressor of A1-7 ventral longitudinal muscle 3 | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Akt^UAS.Exel/Scer\GAL4^ppk.PG is a non-suppressor of larval multidendritic class IV neuron phenotype of path^dg50/Df(3L)BSC773

(Lin et al., 2015)

Akt^UAS.Exel, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Acn^{S641A.S731A.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Akt^UAS.Exel, Scer\GAL4^salm.EPv is a non-suppressor of first posterior wing cell phenotype of Scer\GAL4^salm.EPv, Tcs5^RNAi.UAS.462

(Ibar et al., 2013)

Akt^UAS.Exel, Scer\GAL4^Hml.Δ is a non-suppressor of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Akt^UAS.Exel, Scer\GAL4^elav-C155 is a non-suppressor of adult mushroom body gamma-lobe phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Liévens et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Akt1^{Scer\UAS.Exel} moderately enhances the increased midgut cell size resulting from the expression of Atg9^HMS01246 under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Wen et al., 2017)

The reduced body weight of CycG^HR7 larvae is fully rescued by ectopic expression of Akt1^{Scer\UAS.Exel} driven by Scer\GAL4^Lsp2.PH.

The lipid droplet accumulation in oenocytes of CycG^HR7 mutant larvae is highly suppressed by ectopic expression of Akt1^{Scer\UAS.Exel} under the control of the Scer\GAL4^Lsp2.PH driver.

(Fischer et al., 2015)

Expression of Akt1^{Scer\UAS.Exel} suppresses the reductions in trichome density and overall wing size seen when trbl^{Scer\UAS.T:Zzzz\FLAG} is expressed under the control of Scer\GAL4^e16A.

Expression of trbl^{Scer\UAS.T:Zzzz\FLAG} suppresses the increase in head size seen when Akt1^{Scer\UAS.Exel} is expressed in the eye and head under the control of Scer\GAL4^GMR.long.

Expression of trbl^{Scer\UAS.T:Zzzz\FLAG} suppresses the increase in fibre breadth seen in larval muscles when Akt1^{Scer\UAS.Exel} is expressed under the control of Scer\GAL4^Mef2.PR.

Expression of trbl^{Scer\UAS.T:Zzzz\FLAG} suppresses the increase in cell and nucleus size seen when Akt1^{Scer\UAS.Exel} is expressed under in the larval fat body the control of Scer\GAL4^ppl.PP.

Expression of trbl^{Scer\UAS.T:Zzzz\FLAG} suppresses the downward wing bending phenotype seen when Akt1^{Scer\UAS.Exel} is expressed under the control of Scer\GAL4^ap-md544, resulting in a nearly flat wing blade.

(Das et al., 2014)

Overexpression of Akt1^{Scer\UAS.Exel} in the salivary glands, under the control of Scer\GAL4^ppl.PP, fully suppresses the small cell size phenotype found upon knockdown of CdsA through expression of CdsA^NIG.7962R. The ectopic lipid accumulation phenotype of CdsA^NIG.7962R mutants is unaffected by overexpression of Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} but not Akt1^{Scer\UAS.Exel}.

(Liu et al., 2014)

Scer\GAL4^GMR.PF-driven expression of Akt1^{Scer\UAS.Exel} enhances the rough eye phenotype of the Acn^Scer\UAS.cNa transgene.

Scer\GAL4^GMR.PF-driven expression of Akt1^{Scer\UAS.Exel} fails to affect the rough eye phenotype of the Acn^{S641A.S731A.Scer\UAS} transgene.

(Nandi et al., 2014)

The reduction in the distance between wing veins 3 and 4 that is seen in animals expressing Prpk^{dsRNA.Scer\UAS.462} under the control of Scer\GAL4^salm.EPv is not suppressed if they are also co-expressing Akt1^{Scer\UAS.Exel}.

Clones expressing Prpk^{dsRNA.Scer\UAS.462} and also co-expressing Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^Act5C.PU in the third larval instar wing disc and fat body are small and apoptotic, showing the same phenotype as clones expressing Prpk^{dsRNA.Scer\UAS.462} alone under the control of Scer\GAL4^Act5C.PU.

(Ibar et al., 2013)

Over-expression of wdb^GS9548 in eye imaginal discs (under the control of Scer\GAL4^GMR.long) suppresses the increase in eye size caused by overexpression of Akt1^{Scer\UAS.Exel}.

(Funakoshi et al., 2011)

Expression of Akt1^{Scer\UAS.Exel} under the control of Scer\GAL4^fat does not rescue lipid levels in Sik3⁴⁸ flies.

(Wang et al., 2011)

Co-expression of Sesn^d04539 with Akt^UAS.Exel via Scer\GAL4^ap-md544 suppresses the Akt^UAS.Exel hyperplastic wing phenotype.

The growth-promoting effect of Akt^UAS.Exel overexpression via Scer\GAL4^ap-md544 is enhanced in a homozygous Df(2R)Sesn-8A11-mutant background.

(Lee et al., 2010)

Co-expression of Girdin^{dsRNA.Scer\UAS} suppresses the elevation of cell size in the posterior of the wing seen when Akt1^{Scer\UAS.Exel} is over-expressed using Scer\GAL4^en-e16E.

(Puseenam et al., 2009)

Xenogenetic Interactions

Statement

Reference

Co-expression of Akt1^{Scer\UAS.Exel} enhances the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

(Chuang et al., 2014)

Expression of Akt1^{Scer\UAS.Exel} does not suppress the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

(Sinenko et al., 2010)

Expression of Akt1^{Scer\UAS.Exel} strongly suppresses the pigment cell degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Akt1^{Scer\UAS.Exel} markedly slows down the progressive photoreceptor degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the γ-lobe kenyon cell degeneration seen in the mushroom bodies when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the reduction in lifespan seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of any of Scer\GAL4^elav-C155, Scer\GAL4^repo.PU or Scer\GAL4^Eaat1.PR.

Expression of Akt1^{Scer\UAS.Exel} does not suppress the locomotor defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. The locomotor defects seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^repo.PU are partially suppressed.

(Liévens et al., 2008)

Complementation and Rescue Data

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Mutant

Wild-type

Stocks (2)

Bloomington

8191

y¹ w¹¹¹⁸; P{UAS-Akt.Exel}2

8192

P{UAS-Akt.Exel}1, y¹ w¹¹¹⁸

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Akt1^{Scer\UAS.Exel}

Akt1^UAS.Exel

Akt^UAS.Exel

Name Synonyms

Secondary FlyBase IDs

References (45)

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