FB2025_01 , released February 20, 2025
Allele: Dmel\Adgf-AUAS.Tag:MYC
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General Information
Symbol
Dmel\Adgf-AUAS.Tag:MYC
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Dolezal
FlyBase ID
FBal0157456
Feature type
allele
Associated gene
Dmel\Adgf-A
Associated Insertion(s)
Carried in Construct
P{UAS-Adgf-A.myc}
Also Known As
UAS-ADGF-A
Key Links
Transgenic product class
cDNA
(Dolezal et al., 2005)
wild_type
(Dolezal et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Dolezal et al., 2005)
wild_type
(Dolezal et al., 2005)
Mutagen
in vitro construct
(Dolezal et al., 2005, Dolezal et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-Adgf-A.myc}
Cytology
Description

UASt regulatory sequences drive expression of a wild-type Adgf-A cDNA which is tagged at the C-terminal end with Tag:MYC.

(Dolezal et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Adgf-A
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act.PU/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4c564/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4e33C/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Act.PU/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4e33C/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4c564/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Act5C.PI/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Gerda

      (Dolezal et al., 2003)

      Scer\GAL4Act5C.PI/Adgf-AUAS.Tag:MYC rescues Dp(3;3)Karel

      (Dolezal et al., 2003)
      Partially rescues

      Scer\GAL45015/Adgf-AUAS.Tag:MYC partially rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Cg.PA/Adgf-AUAS.Tag:MYC partially rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Ugt36A1.PK/Adgf-AUAS.Tag:MYC partially rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Cg.PA/Adgf-AUAS.Tag:MYC partially rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL45015/Adgf-AUAS.Tag:MYC partially rescues Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Ugt36A1.PK/Adgf-AUAS.Tag:MYC partially rescues Dp(3;3)Karel

      (Dolezal et al., 2005)
      Fails to rescue

      Scer\GAL4Lsp2.PH/Adgf-AUAS.Tag:MYC fails to rescue Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Mef2.PR/Adgf-AUAS.Tag:MYC fails to rescue Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4T110/Adgf-AUAS.Tag:MYC fails to rescue Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4T110/Adgf-AUAS.Tag:MYC fails to rescue Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Mef2.PR/Adgf-AUAS.Tag:MYC fails to rescue Dp(3;3)Karel

      (Dolezal et al., 2005)

      Scer\GAL4Lsp2.PH/Adgf-AUAS.Tag:MYC fails to rescue Dp(3;3)Karel

      (Dolezal et al., 2005)
      Comments

      Expression of Adgf-AScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Act.PU completely rescues the mutant phenotype of Dp(3;3)Karel animals.

      The lethality and melanotic tumour phenotypes of Dp(3;3)Karel homozygotes are fully rescued by expression of Adgf-AScer\UAS.T:Hsap\MYC under the control of one of Scer\GAL4e33C, Scer\GAL4Cg.PA or Scer\GAL4c564.

      Expression of Adgf-AScer\UAS.T:Hsap\MYC under the control of Scer\GAL4e33C or Scer\GAL4c564 reduces the number of circulating hemocytes in Dp(3;3)Karel third instar larvae to normal levels. Expression of Adgf-AScer\UAS.T:Hsap\MYC under the control of Scer\GAL4Cg.PA also reduces the number of circulating hemocytes in Dp(3;3)Karel third instar larvae, but to a lesser extent.

      (Dolezal et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Adgf-AScer\UAS.T:Hsap\MYC
      Adgf-AScer\UAS.cDa
      Adgf-AUAS.Tag:MYC
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Dolezal
      (Dolezal et al., 2005, Dolezal et al., 2003)
      Secondary FlyBase IDs
        References (5)