Open Close
General Information
Symbol
Dmel\AP-1μSHE-11
Species
D. melanogaster
Name
FlyBase ID
FBal0157515
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
AP47SHE11
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

A region of 37bp is deleted and replaced by 5bp (GTCGG). This results in a frameshift and premature translation termination. A protein of 682 amino acids is produced, the last 29 of which are unrelated to wild type ey sequence. Position of mutation on reference sequence inferred by FlyBase curator.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of sequences encoding amino acid residues 146-158, resulting in a predicted frameshift.

37 nucleotide deletion resulting in the deletion of amino acids 146 to 158 and a frameshift.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

AP-1μSHE-11 ddaC neuron clones within mosaic individuals do not present significant dendrite pruning defects at 16h after puparium formation, as compared to controls.

Eyes containing AP-47SHE-11 clones are rough.

Irregularly aligned photoreceptor cells are observed in AP-47SHE-11 eye disc clones.

11% of AP-47SHE-11 mutant adult sensory organ clones contain extra socket cells.

Homozygous AP-47SHE-11 mutant clones cells induced in third instar larval salivary gland cells either lack detectable glue granules or accumulate small granules in the cytoplasm. AP-47SHE-11 mutant cells also appear smaller than wild type. AP-47SHE-11/+ cells are of an intermediate size, suggesting that AP-47SHE-11 is dosage dependent.

The glue granules of AP-47SHE-11/AP-47EP1112 mutant third instar larvae are smaller than wild type, but larger than those seen in homozygous AP-47SHE-11 mutant larvae.

Salivary gland cell growth (which normally occurs in the third larval instar, starting at the distal end of the gland) is defective in AP-47EP1112/AP-47SHE-11 third instar larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

AP-1μSHE-11 is an enhancer of visible phenotype of Psn9/Psn143

Other
Phenotype Manifest In
Suppressed by
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

AP-1μSHE-11 is an enhancer of eye phenotype of Psn9/Psn143

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

A DlRevF10 SerRX106 double mutant background suppresses the extra socket cell phenotype seen in AP-47SHE-11 thorax clones, instead producing the external sensory cell loss and excess neurons seen in DlRevF10 SerRX106 double mutants.

AP-47SHE-11 suppresses the external sensory cell loss and excess neurons seen in WASp3 mutant thorax clones, instead producing the extra socket cell phenotype seen in AP-47SHE-11 mutants alone.

spdoG104 suppresses the extra socket cell phenotype seen in AP-47SHE-11 thorax clones, instead producing the external sensory cell loss and excessive neurons seen in spdoG104 mutants alone.

AP-47SHE-11 Psn9/Psn143 flies show wing vein thickening and low penetrance pupal lethality.

AP-47SAE-10/AP-47SHE-11 Psn9/Psn143 flies have dorsal and ventral wing notching, enhanced wing vein thickening and show loss of notal microchaetae.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (8)