FlyBase Allele Report: Dmel\AP-1μ[SHE-11]

General Information

Symbol

Dmel\AP-1μ^SHE-11

Species

D. melanogaster

Name

FlyBase ID

FBal0157515

Feature type

allele

Associated gene

Dmel\AP-1μ

Associated Insertion(s)

Carried in Construct

Also Known As

AP47^SHE11

Genomic Maps

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Help me choose

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Benhra et al., 2011)

Mutagen

ethyl methanesulfonate

(Mahoney et al., 2006, Parks, 2004.5.6)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

deletion

3R:9,558,777..9,558,813 [-]

Comment:

A region of 37bp is deleted and replaced by 5bp (GTCGG). This results in a frameshift and premature translation termination. A protein of 682 amino acids is produced, the last 29 of which are unrelated to wild type ey sequence. Position of mutation on reference sequence inferred by FlyBase curator.

(Parks, 2004.5.6)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Deletion of sequences encoding amino acid residues 146-158, resulting in a predicted frameshift.

(Mahoney et al., 2006)

37 nucleotide deletion resulting in the deletion of amino acids 146 to 158 and a frameshift.

(Parks, 2004.5.6)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

lethal - all die before end of embryonic stage

(Burgess et al., 2011)

lethal - all die before end of first instar larval stage (with Df(3R)Exel6264)

(Benhra et al., 2011)

some die during embryonic stage

(Burgess et al., 2011)

some die during first instar larval stage (with Df(3R)Exel6264)

(Benhra et al., 2011)

viable (with AP-1μ^EP1112)

(Burgess et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

AP-1μ^SHE-11 ddaC neuron clones within mosaic individuals do not present significant dendrite pruning defects at 16h after puparium formation, as compared to controls.

(Zong et al., 2018)

Eyes containing AP-47^SHE-11 clones are rough.

Irregularly aligned photoreceptor cells are observed in AP-47^SHE-11 eye disc clones.

(Kametaka et al., 2012)

11% of AP-47^SHE-11 mutant adult sensory organ clones contain extra socket cells.

(Benhra et al., 2011)

Homozygous AP-47^SHE-11 mutant clones cells induced in third instar larval salivary gland cells either lack detectable glue granules or accumulate small granules in the cytoplasm. AP-47^SHE-11 mutant cells also appear smaller than wild type. AP-47^SHE-11/+ cells are of an intermediate size, suggesting that AP-47^SHE-11 is dosage dependent.

The glue granules of AP-47^SHE-11/AP-47^EP1112 mutant third instar larvae are smaller than wild type, but larger than those seen in homozygous AP-47^SHE-11 mutant larvae.

(Burgess et al., 2011)

Salivary gland cell growth (which normally occurs in the third larval instar, starting at the distal end of the gland) is defective in AP-47^EP1112/AP-47^SHE-11 third instar larvae.

(Peng et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

AP-1μ^SHE-11 is an enhancer of visible phenotype of Psn⁹/Psn¹⁴³

(Mahoney et al., 2006)

Other

Statement

Reference

AP-1μ^SHE-11, Psn⁹/Psn¹⁴³ has visible phenotype

(Mahoney et al., 2006)

AP-1μ^SHE-11/AP-1μ^SAE-10, Psn⁹/Psn¹⁴³ has visible phenotype

(Mahoney et al., 2006)

AP-1μ^SHE-11, Psn⁹/Psn¹⁴³ has some die during P-stage phenotype

(Mahoney et al., 2006)

Phenotype Manifest In

Suppressed by

Statement

Reference

AP-1μ^SHE-11 has tormogen cell | supernumerary | somatic clone phenotype, suppressible by Ser^RX106/Dl^RevF10

(Benhra et al., 2011)

AP-1μ^SHE-11 has tormogen cell | supernumerary | somatic clone phenotype, suppressible by spdo^G104

(Benhra et al., 2011)

NOT suppressed by

Statement

Reference

AP-1μ^SHE-11 has tormogen cell | supernumerary | somatic clone phenotype, non-suppressible by WASp³

(Benhra et al., 2011)

Enhancer of

Statement

Reference

AP-1μ^SHE-11 is an enhancer of eye phenotype of Psn⁹/Psn¹⁴³

(Mahoney et al., 2006)

Suppressor of

Statement

Reference

AP-1μ^SHE-11 is a suppressor of external sensory organ | somatic clone phenotype of WASp³

(Benhra et al., 2011)

AP-1μ^SHE-11 is a suppressor of external sensory organ | somatic clone phenotype of spdo^G104

(Benhra et al., 2011)

NOT Suppressor of

Statement

Reference

AP-1μ^SHE-11 is a non-suppressor | somatic clone of external sensory organ phenotype of Dl^RevF10, Ser^RX106

(Benhra et al., 2011)

Other

Statement

Reference

AP-1μ^SHE-11, Psn⁹/Psn¹⁴³ has wing vein phenotype

(Mahoney et al., 2006)

AP-1μ^SHE-11/AP-1μ^SAE-10, Psn⁹/Psn¹⁴³ has wing vein phenotype

(Mahoney et al., 2006)

AP-1μ^SHE-11/AP-1μ^SAE-10, Psn⁹/Psn¹⁴³ has wing phenotype

(Mahoney et al., 2006)

AP-1μ^SHE-11/AP-1μ^SAE-10, Psn⁹/Psn¹⁴³ has microchaeta phenotype

(Mahoney et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

A Dl^RevF10 Ser^RX106 double mutant background suppresses the extra socket cell phenotype seen in AP-47^SHE-11 thorax clones, instead producing the external sensory cell loss and excess neurons seen in Dl^RevF10 Ser^RX106 double mutants.

AP-47^SHE-11 suppresses the external sensory cell loss and excess neurons seen in WASp³ mutant thorax clones, instead producing the extra socket cell phenotype seen in AP-47^SHE-11 mutants alone.

spdo^G104 suppresses the extra socket cell phenotype seen in AP-47^SHE-11 thorax clones, instead producing the external sensory cell loss and excessive neurons seen in spdo^G104 mutants alone.

(Benhra et al., 2011)

AP-47^SHE-11 Psn⁹/Psn¹⁴³ flies show wing vein thickening and low penetrance pupal lethality.

AP-47^SAE-10/AP-47^SHE-11 Psn⁹/Psn¹⁴³ flies have dorsal and ventral wing notching, enhanced wing vein thickening and show loss of notal microchaetae.

(Mahoney et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8190

y¹; speck¹; Psn¹⁴³ AP-1μ^SHE-11/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

AP-1μ^SHE-11

(Zong et al., 2018)

AP-47^SHE-11

AP-47^SHE11

(Benhra et al., 2011)

AP47^SHE11

(Kametaka et al., 2012, Peng et al., 2009, Peng et al., 2009)

SHE-11

(Mahoney et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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