Allele Dmel\topi^Z3-3767

General Information
Symbol	Dmel\topi^Z3-3767	Species	D. melanogaster
Name		FlyBase ID	FBal0158554
Feature type	allele	Associated gene	Dmel\topi

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Perezgasga et al., 2004)
Mutagen	ethyl methanesulfonate (Perezgasga et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:5,602,674..5,602,674 comment=Position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental na_change=G5602674A pr_change=G517D\|topi-PA reported_na_change=G1550A reported_pr_change=G516D (Perezgasga et al., 2004)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: G1550A. Amino acid replacement: G516D. (Perezgasga et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	female fertile (Perezgasga et al., 2004) male sterile (Perezgasga et al., 2004) meiotic cell cycle defective \| male (Perezgasga et al., 2004) viable (Perezgasga et al., 2004)
Phenotype Manifest In
	primary spermatocyte & nuclear chromosome (Perezgasga et al., 2004) primary spermatocyte & nuclear chromosome (with Df(3R)by10) (Perezgasga et al., 2004) secondary spermatocyte (Perezgasga et al., 2004) spermatid (Perezgasga et al., 2004)
Detailed Description
	Statement Reference The testes of topi^Z3-3767/topi^Z3-3767 adult males contain germ cell cysts up to and including mature primary spermatocytes, but few spermatocytes undergo meiotic division. The mature spermatocytes present in topi^Z3-3767/Df(3R)by10 or topi^Z3-3767 homozygous mutant testes resemble wild-type mature primary spermatocytes but have a more compact chromosomal morphology than wild-type primary spermatocytes in late G2, immediately prior to the onset of meiosis. (Perezgasga et al., 2004)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Zuker
	From C.Zucker's collection of viable, male sterile lines. (Perezgasga et al., 2004)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	topi^Z3-3767
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Perezgasga et al., 2004, Development 131(8): 1691--1702 Regulation of transcription of meiotic cell cycle and terminal differentiation genes by the testis-specific Zn-finger protein matotopetli. [FBrf0174565]

Allele Dmel\topiZ3-3767

Allele Dmel\topi^Z3-3767