Allele Dmel\tefu^unspecified

General Information
Symbol	Dmel\tefu^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0158583
Feature type	allele	Associated gene	Dmel\tefu

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage (Bi et al., 2005)
Phenotype Manifest In
	anaphase & condensed nuclear chromosome (Oikemus et al., 2004) chromosome & neuroblast \| third instar larval stage 2 (Bi et al., 2005) eye (Song et al., 2004) interommatidial bristle (Song et al., 2004) ommatidium (Song et al., 2004)
Detailed Description
	Statement Reference Third instar larval neuroblasts of tefu^unspecified mutants have an average of 3 fused chromosome ends per cell. (Bi et al., 2005) Anaphase bridges are sometimes seen in mutant imaginal discs. (Oikemus et al., 2004) Escaper adult homozygotes have eyes that are smaller than normal, have a rough phenotype and are missing some bristles. Mutant wing discs contain significantly more mitotic cells 25 minutes after irradiation compared to control wild-type discs. At later time points following irradiation, G2 arrest occurs normally in mutant wing discs. (Song et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference mei-41^29D, tefu^unspecified has developmental rate defective \| wandering third instar larval stage phenotype (Bi et al., 2005) mei-41^29D, tefu^unspecified has lethal \| wandering third instar larval stage phenotype (Bi et al., 2005) mei-41^RT1, tefu^unspecified has developmental rate defective \| wandering third instar larval stage phenotype (Bi et al., 2005) mei-41^RT1, tefu^unspecified has lethal \| wandering third instar larval stage phenotype (Bi et al., 2005) mei-41^unspecified, tefu^unspecified has melanotic mass phenotype phenotype (Song et al., 2004, Song et al., 2004)
Phenotype Manifest In
Enhanced by
Statement Reference tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, enhanceable by mei-41^29D (Bi et al., 2005) tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, enhanceable by mei-41^D9 (Bi et al., 2005) tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, enhanceable by mei-41^RT1 (Bi et al., 2005) tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, enhanceable by mus304^D1/mus304^D1 (Bi et al., 2005) tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, enhanceable by mus304^D3/mus304^D1 (Bi et al., 2005) tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, enhanceable by mus304^D3/mus304^D3 (Bi et al., 2005)
NOT Enhanced by
Statement Reference tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, non-enhanceable by grp⁰⁶⁰³⁴ (Bi et al., 2005) tefu^unspecified has chromosome & neuroblast \| third instar larval stage 2 phenotype, non-enhanceable by lok^p6 (Bi et al., 2005)
Other
Statement Reference mei-41^unspecified, tefu^unspecified has melanotic mass phenotype (Song et al., 2004, Song et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference The chromosome fusion phenotype seen in third instar larval neuroblasts of tefu^unspecified mutants is enhanced from an average of approximately 3 fusions per nucleus to an average of approximately 5 per nucleus by mei-41^D9. mei-41^29D and mei-41^RT1 are stronger enhancers of this phenotype (7 fusions per nucleus), with the latter also causing polyploidy in 19% of cases. In these polyploid nuclei, most chromosome ends are fused. This phenotype is also weakly enhanced by mus304^D3/mus304^D3 and more strongly enhanced by mus304^D1/mus304^D3 (5.35 fusions on average) and mus304^D1/mus304^D1 (7.12 fusions per nucleus and 20% of these nuclei are polyploid). tefu^unspecified; mei-41^RT1 and tefu^unspecified; mei-41^29D double mutants develop more slowly than wild-type animals and arrest as third instar larvae for several days before death. There are fewer mitotic cells in the proliferating tissues of these double mutants. (Bi et al., 2005) mei-41^unspecified tefu^unspecified double mutant third instar larvae usually have melanotic tumours. (Song et al., 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	tefu^unspecified is rescued by Scer\GAL4^unspecified/tefu^Scer\UAS.cOa (Oikemus et al., 2004) tefu^unspecified is rescued by tefu^+t14.5 (Silva et al., 2004)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	atm^- (Oikemus et al., 2004) tefu^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Frydrychova et al., 2008, Genetics 180(1): 121--131 HP1 is distributed within distinct chromatin domains at Drosophila telomeres. [FBrf0206935] Bi et al., 2005, Proc. Natl. Acad. Sci. U.S.A. 102(42): 15167--15172 Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. [FBrf0191425] Oikemus et al., 2004, Genes Dev. 18(15): 1850--1861 Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. [FBrf0179362] Silva et al., 2004, Curr. Biol. 14(15): 1341--1347 ATM is required for telomere maintenance and chromosome stability during Drosophila development. [FBrf0180052] Song et al., 2004, Curr. Biol. 14(15): 1354--1359 The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. [FBrf0180054]

Allele Dmel\tefuunspecified

Allele Dmel\tefu^unspecified