FB2025_01 , released February 20, 2025
Allele: Dmel\stgEY12388
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General Information
Symbol
Dmel\stgEY12388
Species
D. melanogaster
Name
FlyBase ID
FBal0158600
Feature type
allele
Associated gene
Dmel\stg
Associated Insertion(s)
P{EPgy2}stgEY12388
Carried in Construct
Also Known As
stringEY12388
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}stgEY12388
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis
      modeled by Hsap\TARDBPUAS.cHa
      (Zhan et al., 2013)
      ameliorates  ataxia telangiectasia
      modeled by tefuRNAi.UAS
      (Rimkus et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wings of flies heterozygous for stgEY12388 are found to be slightly smaller than that of wild-type flies.

      (Swaminathan and Pile, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      stg[+]/stgEY12388 is a suppressor | partially of abdomen phenotype of mir-965KO1/mir-965KO2

      (Verma and Cohen, 2015)

      stg[+]/stgEY12388 is a suppressor | partially of histoblast phenotype of mir-965KO1/mir-965KO2

      (Verma and Cohen, 2015)

      stg[+]/stgEY12388 is a suppressor of eye photoreceptor cell | third instar larval stage phenotype of Scer\GAL4elav.PU, tefuRNAi.UAS

      (Rimkus et al., 2008)

      stg[+]/stgEY12388 is a suppressor of eye phenotype of Scer\GAL4GMR.PU, tefuRNAi.UAS

      (Rimkus et al., 2008)

      stg[+]/stgEY12388 is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4GMR.PU, tefuRNAi.UAS

      (Rimkus et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of stgEY12388 partially suppresses the segment gap phenotype seen in the abdomens of mir-965KO1/mir-965KO2 mutant flies. The asynchronous histoblast division and reduction in histoblast migration rate are also suppressed.

      (Verma and Cohen, 2015)

      stgEY12388/+ suppresses the rough-eye phenotype and increases the number of normal photoreceptors per ommatidium in flies expressing tefudsRNA.Scer\UAS under the control of Scer\GAL4GMR.PU. Significantly reduced severity of progressive neurodegeneration is also observed in these animals.

      Expression of tefudsRNA.Scer\UAS under the control of Scer\GAL4elav.PU results in increased levels of photoreceptor cell division in third instar larval eye discs, which is suppressed by stgEY12388/+.

      (Rimkus et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference

      stgEY12388 appears to extend the lifespan of a subset of Scer\GAL4D42>Hsap\TARDBPScer\UAS.cHa flies. Further analysis reveals that the lifespan extension is restricted to female flies.

      (Zhan et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      StgEY12388
      (Rimkus et al., 2008)
      stgEY12388
      (Verma and Cohen, 2015)
      stgEY
      (Verma and Cohen, 2015)
      Name Synonyms
      stringEY12388
      (Zhan et al., 2013, Rimkus et al., 2008)
      Secondary FlyBase IDs
        References (5)