FB2025_01 , released February 20, 2025
Allele: Dmel\parkc00062
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General Information
Symbol
Dmel\parkc00062
Species
D. melanogaster
Name
FlyBase ID
FBal0158827
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
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Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Disease
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Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

parkc00062 homozygotes show significant developmental delay (especially at late third instar larval and pupal stages), increased pupal lethality, reduced pupation height index (height travelled by late third instar larvae before pupation) regardless of larval density, decreased body size and mass and reduced adult survival rate relative to controls. parkc00062 adults are short lived, flightless, show age-progressive drooping wing phenotype (penetrance increases with age) as well as progressive decline of climbing abilities.

Adult parkc00062 mutant flies are highly susceptible to Listeria monocytogenes, Salmonella enterica and Mycobacterium marinum infections and display significantly lower survival rate upon infection as well as higher post-infection pathogen load compared to wild-type.

External Data
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Xenogenetic Interactions
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Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)