parkc00062 homozygotes show significant developmental delay (especially at late third instar larval and pupal stages), increased pupal lethality, reduced pupation height index (height travelled by late third instar larvae before pupation) regardless of larval density, decreased body size and mass and reduced adult survival rate relative to controls. parkc00062 adults are short lived, flightless, show age-progressive drooping wing phenotype (penetrance increases with age) as well as progressive decline of climbing abilities.
Adult parkc00062 mutant flies are highly susceptible to Listeria monocytogenes, Salmonella enterica and Mycobacterium marinum infections and display significantly lower survival rate upon infection as well as higher post-infection pathogen load compared to wild-type.
parkc00062 is an enhancer of visible phenotype of Scer\GAL4GMR.PF, cindrRNAi.PC.PD.UAS
parkc00062 is an enhancer of eye phenotype of Scer\GAL4GMR.PF, cindrRNAi.PC.PD.UAS