Allele Dmel\mio¹

General Information
Symbol	Dmel\mio¹	Species	D. melanogaster
Name		FlyBase ID	FBal0158955
Feature type	allele	Associated gene	Dmel\mio

Map ( GBrowse )
Allele class	antimorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	antimorphic allele - genetic evidence (Iida and Lilly, 2004)
Mutagen	ethyl methanesulfonate (Iida and Lilly, 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:2,217,866..2,217,867 reported_pr_change=W110@ comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified) evidence=experimental pr_change=W110@\|mio-PA (Iida and Lilly, 2004)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: W110@. (Iida and Lilly, 2004)
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (with mio²) (Iida and Lilly, 2004) female sterile \| recessive (Iida and Lilly, 2004)
Phenotype Manifest In
	egg chamber (with mio²) (Senger et al., 2011) nurse cell (Iida and Lilly, 2004) nurse cell (with mio²) (Iida and Lilly, 2004) oocyte (Iida and Lilly, 2004) oocyte (with mio²) (Iida and Lilly, 2004)
Detailed Description
	Statement Reference In mio[1]/mio[2] mutants, the vast majority of egg chambers arrest prior to stage 5 of oogenesis, well before the start of vitellogenesis in stage 7. (Senger et al., 2011) 81% of egg chambers in mio¹ homozygotes have 16-polyploid nurse cells and no oocyte. These egg chambers rarely develop beyond stage 5 of oogenesis. This is a higher penetrance than seen for mio¹/Df(2L)yan-J2 (64%), suggesting that mio¹ is a weak antimorph. (Iida and Lilly, 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference mio²/mio¹ has egg chamber phenotype, suppressible \| partially by Nup44A[+]/Nup44A^EP2417 (Senger et al., 2011) mio²/mio¹ has egg chamber phenotype, suppressible by Df(2R)ED1735/+ (Senger et al., 2011) mio²/mio¹ has egg chamber phenotype, suppressible by Nup44A^Δ15/Nup44A[+] (Senger et al., 2011) mio²/mio¹ has nurse cell phenotype, suppressible \| partially by mei-W68[+]/mei-W68¹ (Iida and Lilly, 2004) mio²/mio¹ has nurse cell phenotype, suppressible \| partially by mei-W68[+]/mei-W68^k05603 (Iida and Lilly, 2004) mio²/mio¹ has oocyte phenotype, suppressible \| partially by mei-W68[+]/mei-W68¹ (Iida and Lilly, 2004) mio²/mio¹ has oocyte phenotype, suppressible \| partially by mei-W68[+]/mei-W68^k05603 (Iida and Lilly, 2004)
Additional Comments
Genetic Interactions
Statement Reference Nup44A[EP2417]/+ partially suppresses the mio[1]/mio[2] oogenesis phenotype. In contrast to mio[1]/mio[2] single mutants, egg chambers from Nup44A[EP2417]/+, mio[1]/mio[2] females frequently progress through vitellogenesis to produce mature eggs. Moreover, a small percentage of the eggs laid by Nup44A[EP2417]/+, mio[1]/mio[2] females hatch and develop into viable adults. The percentage of mio[1]/mio[2] mutant egg chambers with an oocyte increases 6-fold in a Df(2R)ED1735/+ genetic background. The percentage of mio[1]/mio[2] mutant egg chambers with an oocyte increases 6-fold in a Nup44A[Δ15]/+ genetic background. (Senger et al., 2011) Transformation of oocytes to nurse cells in mio²/mio¹ females is suppressed by mei-W68¹/+ or mei-W68^k05603/+. (Iida and Lilly, 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Identified in a screen for mutants that alter the cell cycle of the ovarian cyst. (Iida and Lilly, 2004)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	mio¹ (Senger et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Senger et al., 2011, Development 138(10): 2133--2142 The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. [FBrf0213566] Iida and Lilly, 2004, Development 131(5): 1029--1039 missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. [FBrf0174551]

Allele Dmel\mio1

Allele Dmel\mio¹