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General Information
Symbol
Dmel\mio1
Species
D. melanogaster
Name
FlyBase ID
FBal0158955
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
G2217866A
Amino acid change:
W110term | mio-PA
Reported amino acid change:
W110term
Comment:
G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: W110term.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Egg chambers from mio1/mio2 females often develop without an oocyte and cease to develop beyond stage 5 or 6 of oogenesis.
In mio1/mio2 mutants, the vast majority of egg chambers arrest prior to stage 5 of oogenesis, well before the start of vitellogenesis in stage 7.
81% of egg chambers in mio1 homozygotes have 16-polyploid nurse cells and no oocyte. These egg chambers rarely develop beyond stage 5 of oogenesis. This is a higher penetrance than seen for mio1/Df(2L)yan-J2 (64%), suggesting that mio1 is a weak antimorph.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
mio2/mio1 has egg chamber phenotype, suppressible | partially by Nup44A[+]/Nup44AEP2417
mio2/mio1 has egg chamber phenotype, suppressible by Df(2R)ED1735/+
mio2/mio1 has egg chamber phenotype, suppressible by Nup44AΔ15/Nup44A[+]
mio2/mio1 has nurse cell phenotype, suppressible | partially by mei-W68[+]/mei-W681
mio2/mio1 has oocyte phenotype, suppressible | partially by mei-W68[+]/mei-W681
mio2/mio1 has nurse cell phenotype, suppressible | partially by mei-W68[+]/mei-W68k05603
mio2/mio1 has oocyte phenotype, suppressible | partially by mei-W68[+]/mei-W68k05603
Additional Comments
Genetic Interactions
Statement
Reference
Nup44AEP2417/+ partially suppresses the mio1/mio2 oogenesis phenotype. In contrast to mio1/mio2 single mutants, egg chambers from Nup44AEP2417/+, mio1/mio2 females frequently progress through vitellogenesis to produce mature eggs. Moreover, a small percentage of the eggs laid by Nup44AEP2417/+, mio1/mio2 females hatch and develop into viable adults. The percentage of mio1/mio2 mutant egg chambers with an oocyte increases 6-fold in a Df(2R)ED1735/+ genetic background. The percentage of mio1/mio2 mutant egg chambers with an oocyte increases 6-fold in a Nup44AΔ15/+ genetic background.
Transformation of oocytes to nurse cells in mio2/mio1 females is suppressed by mei-W681/+ or mei-W68k05603/+.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
Identified in a screen for mutants that alter the cell cycle of the ovarian cyst.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)