FB2025_01 , released February 20, 2025
Allele: Dmel\Ire1f02170
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General Information
Symbol
Dmel\Ire1f02170
Species
D. melanogaster
Name
FlyBase ID
FBal0159138
Feature type
allele
Associated gene
Dmel\Ire1
Associated Insertion(s)
PBac{WH}Ire1f02170
Carried in Construct
Also Known As
Pire1f02170
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{WH}Ire1f02170
Cytology
Description
Allele components
Component
Use(s)
Inserted element
PBac{WH}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease 1
      modeled by Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
      (Tsuda et al., 2017)
      ameliorates  carcinoma
      modeled by scrib1
      (Zheng et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The interrhabdomeral space is reduced in size in Ire1f02170 mutant clones compared to controls.

      (Coelho et al., 2013)

      Ire1f02170 mutant larvae are significantly smaller than heterozygous controls, and fail to develop beyond the 1st instar larval stage. Flies that are mutant for maternal Ire1f02170 also show first instar larval lethality.

      (Ryoo et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Suppressor of
      Statement
      Reference

      Ire1f02170/Ire1f02170 is a suppressor | partially of melanotic necrosis | somatic clone | adult stage phenotype of scrib1

      (Zheng et al., 2023)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The apoptosis seen in the larval eye discs of animals expressing ninaEG69D.Scer\UAS under the control of Scer\GAL4GMR.PF is enhanced by Ire1f02170.

      (Kang et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ire1f02170 is rescued by Ire1Tag:HA

      (Mitra and Ryoo, 2021)

      Ire1f02170 is rescued by Ire1UAS.cCa/Scer\GAL4GMR.PU

      (Coelho et al., 2013)
      Comments

      Expression of Ire1Scer\UAS.cCa under the control of Scer\GAL4GMR.PU rescues the reduction in interrhabdomeral space size seen in Ire1f02170 mutant clones.

      (Coelho et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ire1f02170
      (Zheng et al., 2023, Brown et al., 2021, Mitra and Ryoo, 2021, Huang et al., 2017, Tsuda et al., 2017, Xu et al., 2016)
      Pire1f02170
      (Cairrão et al., 2022)
      ire-1f02170
      ire1f02170
      (Zhao et al., 2023, Ryoo et al., 2013, Kang et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)