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General Information
Symbol
Dmel\cycΔ.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0159371
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-cycΔ
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a mutant form of cyc which lacks the basic region (codons 31-45) and is tagged with Tag:MYC. Expected to produce a dominant-negative form of cyc.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4P2.4.Pdf show a significant increase in sleep latency compared to controls.

Males expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4desat1.PB show a significant increase in the levels of (z)-7-Tricosene and (z)-7-Pentacosene compared to wild type. These males show a temporal difference in remating behaviour compared to wild type, without affecting the total number of matings.

Flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tim.PE show abnormal temperature entrainment of behavioural rhythms.

Flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nan.PK normal temperature entrainment of behavioural rhythms.

Flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tim.PE are arrhythmic with respect to locomotor activity when assayed for at least 5 days in constant darkness after being entrained to 12 hour light:12 hour dark cycles for 3 days, in contrast to controls which show robust locomotor activity rhythms under these conditions. Only 21% of flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4P2.4.Pdf are arrhythmic with respect to locomotor activity when assayed for at least 5 days in constant darkness after being entrained to 12 hour light:12 hour dark cycles for 3 days, in contrast to controls which show robust locomotor activity rhythms under these conditions. The diurnal changes in the mean electroantennogram (EAG) response to ethyl acetate which are seen in wild-type flies maintained in 12 hour light:12 hour dark cycles are abolished in flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4tim.PE or Scer\GAL4Or83b.2.642.T:Hsim\VP22. The diurnal changes in the mean electroantennogram (EAG) response to ethyl acetate which are seen in wild-type flies maintained in 12 hour light:12 hour dark cycles are abolished in flies expressing cycΔ.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Or22a.8197. However, if the EAG recordings are taken from a more lateral position on the antenna (which is outside the region of Scer\GAL4Or22a.8197 expression), then the EAG responses are rhythmic, albeit at a lower amplitude.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
cycΔ.Scer\UAS.T:Hsap\MYC
cycΔ.UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (8)