FlyBase Allele Report: Dmel\Cyfip[UAS.cSa]

General Information

Symbol

Dmel\Cyfip^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Schenck

FlyBase ID

FBal0159732

Feature type

allele

Associated gene

Dmel\Cyfip

Associated Insertion(s)

Carried in Construct

P{UAS-CYFIP.S}

Also Known As

UAS-CYFIP

Key Links

Transgenic product class

wild_type

(Schenck et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Schenck et al., 2003)

Mutagen

in vitro construct

(Schenck et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-CYFIP.S}

Cytology

Description

UAS sequences drive expression of Sra-1.

(Schenck et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Cyfip

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^elav-C155

(Schenck et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Overexpression of Sra-1^Scer\UAS.cSa under the control of Scer\GAL4^elav-C155 does not result in any defects in the overall morphology of the embryonic nervous system.

(Schenck et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Cyfip^UAS.cSa, Scer\GAL4^P2.4.Pdf is a non-suppressor of abnormal neuroanatomy phenotype of Fmr1^E68K.EP3517, Scer\GAL4^P2.4.Pdf

(Reeve et al., 2008)

Other

Statement

Reference

Cyfip^UAS.cSa, Fmr1^E68K.EP3517, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype

(Reeve et al., 2008)

Cyfip^UAS.cSa, Fmr1^R115H.EP3517, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype

(Reeve et al., 2008)

Cyfip^UAS.cSa, Fmr1^S174F.EP3517, Scer\GAL4^elav.PU has abnormal neuroanatomy phenotype

(Reeve et al., 2008)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Cyfip^UAS.cSa, Scer\GAL4^P2.4.Pdf is a non-suppressor of LNv neuron phenotype of Fmr1^E68K.EP3517, Scer\GAL4^P2.4.Pdf

(Reeve et al., 2008)

Other

Statement

Reference

Cyfip^UAS.cSa, Fmr1^E68K.EP3517, Scer\GAL4^elav.PU has neuromuscular junction phenotype

(Reeve et al., 2008)

Cyfip^UAS.cSa, Fmr1^R115H.EP3517, Scer\GAL4^elav.PU has neuromuscular junction phenotype

(Reeve et al., 2008)

Cyfip^UAS.cSa, Fmr1^S174F.EP3517, Scer\GAL4^elav.PU has neuromuscular junction phenotype

(Reeve et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Sra-1^Scer\UAS.cSa does not suppress the defasciculation of LNv neurons caused by Scer\GAL4^P2.4.Pdf; Fmr1^E68K.EP3517

Co-overexpression of Fmr1^E68K.EP3517 and Sra-1^Scer\UAS.cSa using Scer\GAL4^elav.PU results in a significant neuromuscular junction overgrowth phenotype.

Co-overexpression of Fmr1^R115H.EP3517 and Sra-1^Scer\UAS.cSa using Scer\GAL4^elav.PU results in a significant neuromuscular junction overgrowth phenotype.

Co-overexpression of Fmr1^S174F.EP3517 and Sra-1^Scer\UAS.cSa using Scer\GAL4^elav.PU results in a significant neuromuscular junction overgrowth phenotype.

(Reeve et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Cyfip^UAS.cSa rescues Cyfip^85.1

(Schenck et al., 2004)

Scer\GAL4^elav-C155/Cyfip^UAS.cSa rescues Cyfip^85.1

(Schenck et al., 2003)

Comments

The reduced synaptic length seen at the neuromuscular junction of Sra-1^85.1 larvae is rescued by expression of Sra-1^Scer\UAS.cSa under the control of Scer\GAL4^elav-C155.

(Schenck et al., 2004)

Rescues the midline crossing phenotype seen by longitudinal connectives and the early pupal lethality, in Sra-1^85.1 mutants. This rescue is dose dependant, improving with more copies of P{UAS-CYFIP.S}.

(Schenck et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Cyfip^UAS.cSa

Sra-1^Scer\UAS.cSa

Sra-1^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Schenck

(Schenck et al., 2003)

Secondary FlyBase IDs

References (5)

Report Sections

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