Insertion in the coding sequence, 516bp downstream of the ATG start codon.
Insertion in the second exon.
viable (with Df(2L)T317)
The testes of mutant males show a significant loss of germline stem cells (GSCs), with an average of only 3.4 GSCs per testis (compared to 8.3 GSCs per testis in wild type).
Comparable numbers of marked wild-type and homozygous GSC clones are detected in males 5 and 11 days after clone induction. In all cases spermatogenesis is normal in males containing homozygous GSC clones (normal cysts with 16 differentiating spermatocytes are seen).
The somatic cyst progenitor cells (CPCs) directly contact the hub in the mutant testes, forming a tight circle around it (in wild-type testes the CPCs only make limited contacts to the hub cells through their cytoplasm extensions).
6 days after clone induction, 100% of testes carry one or more marked homozygous CPC clones, with an average of 3.7 marked homozygous CPCs per testis (compared to 92% of testes carrying one or more marked wild-type CPC clones, with an average of 1.1 marked wild-type CPCs per testis).
Homozygotes have normal eyes and normal photoreceptor organisation.
Socs36EEY06665/Socs36EEY06665 is a suppressor of decreased cell number | somatic clone | spermatogenesis phenotype of esgΔ
Socs36EEY06665/Socs36EEY06665 is a suppressor of cyst progenitor cell | somatic clone | decreased number phenotype of esgΔ
Socs36EEY06665 is a suppressor of phenotype of Scer\GAL4VP16.nanos.UTR, upd1UAS.cCa
In 44% of Socs36E178 aptKG05830/Socs36EEY06665 apt167 stage 10 egg chambers the border cells are tethered to the anterior end of the egg chamber by non-cluster associated invasive cells. This inability to detach from neighbouring follicle cells results in a migration delay in 31% of the stage 10 double mutant egg chambers.
Socs36EEY06665 is rescued by Scer\GAL4C587/Socs36EUASp.cCa
Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4C587 rescues the mutant cyst progenitor cell phenotype seen in the testes of Socs36EEY06665 males.
