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General Information
Symbol
Dmel\Ced-12c06760
Species
D. melanogaster
Name
FlyBase ID
FBal0160703
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
elmoPB, elmoPB<up>c06760</up>
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Maternal and zygotic Ced-12c06760 mutants express some wild type transcript as well as two larger products. Aberrant splicing of the primary transcript occurs between exons 1 and 2, and introduces a stop codon 8 amino acids downstream from the end of exon 1.

Insertion components
PBac{PB}Ced-12c06760
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Detached muscle fibres are present in stage 16-17 embryos derived from Ced-12c06760 germ line clones.

In embryos maternally and zygotically mutant for Ced-12c06760, significant axonal patterning defects are observed, including: an increased number of outer fascicle gaps, aberrant midline crossing of longitudinal axons, and misrouting of outer longitudinal axons.

Homozygous embryos have minor defects in myoblast fusion: a small number of myoblasts remain unfused and muscles are occasionally missing.

Ced-12c06760/Df(2L)HO55 embryos exhibit modest myoblast fusion defects: the overall muscle pattern is unperturbed, but some unfused myoblasts are present just under the muscle layer.

Germline clone embryos maternally mutant for Ced-12c06760 and zygotically heterozygous for Df(2L)Prl (that removes Ced-12) exhibit a greater number of missing muscles and unfused myoblasts compared to zygotic Ced-12c06760 trans-heterozygotes. The earlier specification of developing muscle cells, founder cells and fusion-competent cells appears to occur normally in these embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Ced-12Scer\UAS.cGa under the control of Scer\GAL4Act.PU reverts the lethality of Ced-12c06760.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Lethality is reverted by excision of PBac{PB}Ced-12c06760.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)