CHORDc02881/+ flies are viable and morphologically normal.
CHORDc02881/CHORDc02881 flies die as third instar larvae. Mutant larvae are devoid of imaginal discs, and display strongly reduced testes and salivary glands.
Brain preparations from CHORDc02881 mutant larvae show that in 95% of dividing cells the chromosomes are elongated and irregularly condensed. Mutant cells spend more time in mitosis than wild-type control cells. The majority of cells remain arrested in a prophase-metaphase state. Of those that do escape into anaphase, strong defects in chromosome segregation are observed. 30% of mutant neuroblasts are polyploid, compared to 0.2% in control cells. In addition, an increase in the frequency of apoptotic cells is observed in mutant tissue (7.7%) compared to control brain tissue (0.5%).
Supernumerary centrosomes are observed in CHORDc02881 mutant brain cells.