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General Information
Symbol
Dmel\morac02881
Species
D. melanogaster
Name
FlyBase ID
FBal0160739
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mora1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
PBac{PB}morac02881
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

CHORDc02881/+ flies are viable and morphologically normal.

CHORDc02881/CHORDc02881 flies die as third instar larvae. Mutant larvae are devoid of imaginal discs, and display strongly reduced testes and salivary glands.

Brain preparations from CHORDc02881 mutant larvae show that in 95% of dividing cells the chromosomes are elongated and irregularly condensed. Mutant cells spend more time in mitosis than wild-type control cells. The majority of cells remain arrested in a prophase-metaphase state. Of those that do escape into anaphase, strong defects in chromosome segregation are observed. 30% of mutant neuroblasts are polyploid, compared to 0.2% in control cells. In addition, an increase in the frequency of apoptotic cells is observed in mutant tissue (7.7%) compared to control brain tissue (0.5%).

Supernumerary centrosomes are observed in CHORDc02881 mutant brain cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Hsap\CHORDC1Scer\UAS.cFa under the control of Scer\GAL4Act5C.PI in CHORDc02881 mutant flies rescues the imaginal disc and testis phenotype, and these tissues appear mostly normal. Most mitotic divisions observed in brain tissue are completely normal None of the observed mitotic figures were polyploid, and 98% of dividing cells display two centrosomes. These flies still die during metamorphosis.

Complementation and Rescue Data
Not rescued by
Comments

Expression of CHORDScer\UAS.cFa under the control of Scer\GAL4Act5C.PI in CHORDc02881 mutant animals fails to rescue lethality.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
CHORDc02881
morac02881
Name Synonyms
Secondary FlyBase IDs
    References (3)