FlyBase Allele Report: Dmel\srl[EY05931]

General Information

Symbol

Dmel\srl^EY05931

Species

D. melanogaster

Name

FlyBase ID

FBal0160758

Feature type

allele

Associated gene

Dmel\srl

Associated Insertion(s)

P{EPgy2}srl^EY05931

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}srl^EY05931

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:4,429,006..4,429,006 [-]

(Lassetter et al., 2023, Xu et al., 2021, Merzetti and Staveley, 2016, Merzetti and Staveley, 2015, Mukherjee et al., 2014, Mukherjee and Duttaroy, 2013, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA

(Merzetti and Staveley, 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X syndrome

modeled by Fmr1³

(Weisz et al., 2024)

ameliorates Huntington's disease

modeled by Hsap\HTT^{N548.Q128.UAS}

(Martin et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Merzetti and Staveley, 2016)

interommatidial bristle, with Scer\GAL4^GMR.PU

(Merzetti and Staveley, 2015)

interommatidial bristle | decreased number, with Scer\GAL4^GMR.PU

(Merzetti and Staveley, 2016)

ommatidium | decreased number, with Scer\GAL4^GMR.PU

(Merzetti and Staveley, 2016)

ommatidium | increased number | heat sensitive, with Scer\GAL4^GMR.PU

(Merzetti and Staveley, 2015)

Detailed Description

Statement

Reference

At 25[o]C expression of srl^EY05931 driven by Scer\GAL4^GMR.PU slightly decreases the number of ommatidia (non-significant) and bristles (significant) in the eye, and at 29[o]C (increased expression) there is an increase in the number of ommatidia and bristles compared to controls. Expression of srl^EY05931 driven by Scer\GAL4^Ddc.PU significantly decreases lifespan (at either temperature) and leads to a premature loss in climbing ability (25[o]C) over time compared to controls.

(Merzetti and Staveley, 2015)

Male and female flies with over-expression of srl^EY05931 driven by Scer\GAL4^Act.PU show resistance to oxidative stress: flies survive better than controls following exposure to 20mM paraquat.

(Mukherjee et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

srl^EY05931, Scer\GAL4^Act.PU is a suppressor | somatic clone of decreased cell size | somatic clone phenotype of S6k^KQ.UAS, Scer\GAL4^Act.PU

(Mukherjee and Duttaroy, 2013)

srl^EY05931, Scer\GAL4^ap-md544 is a suppressor of visible phenotype of S6k^KQ.UAS, Scer\GAL4^ap-md544

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^Act.PU/srl^EY05931 is a suppressor | partially of decreased cell size | somatic clone phenotype of Scer\GAL4^Act.PU, foxo^UAS.cPa

(Mukherjee and Duttaroy, 2013)

srl^EY05931/Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PU, foxo^UAS.cPa

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^ap-md544/srl^EY05931 is a suppressor | partially of visible phenotype of Scer\GAL4^ap-md544, foxo^UAS.cPa

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^Act.PU/srl^EY05931 is a suppressor | partially | somatic clone of decreased cell size | somatic clone phenotype of Scer\GAL4^Act.PU, mTor^TED.UAS

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^Act.PU/srl^EY05931 is a suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, mTor^TED.UAS

(Mukherjee and Duttaroy, 2013)

NOT Suppressor of

Statement

Reference

srl^EY05931, Scer\GAL4^Mhc.PW is a non-suppressor of visible phenotype of Hsap\PABPN1^17ala.UAS, Scer\GAL4^Mhc.PW

(Chartier et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

srl^EY05931, Scer\GAL4^ppl.PP is a suppressor | partially of embryonic/larval fat body phenotype of Nadk1a^NIG.6145R, Scer\GAL4^ppl.PP

(Xu et al., 2021)

srl^EY05931, Scer\GAL4^ppl.PP is a suppressor | partially of mitochondrion | larval stage phenotype of Nadk1a^NIG.6145R, Scer\GAL4^ppl.PP

(Xu et al., 2021)

srl^EY05931, Scer\GAL4^ppl.PP is a suppressor | partially of embryonic/larval fat body phenotype of FASN1^HM05141, Scer\GAL4^ppl.PP

(Xu et al., 2021)

srl^EY05931, Scer\GAL4^ppl.PP is a suppressor | partially of mitochondrion | larval stage phenotype of FASN1^HM05141, Scer\GAL4^ppl.PP

(Xu et al., 2021)

srl^EY05931, Scer\GAL4^ap-md544 is a suppressor of wing phenotype of S6k^KQ.UAS, Scer\GAL4^ap-md544

(Mukherjee and Duttaroy, 2013)

srl^EY05931/Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, foxo^UAS.cPa

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^ap-md544/srl^EY05931 is a suppressor | partially of wing phenotype of Scer\GAL4^ap-md544, foxo^UAS.cPa

(Mukherjee and Duttaroy, 2013)

Scer\GAL4^Act.PU/srl^EY05931 is a suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, mTor^TED.UAS

(Mukherjee and Duttaroy, 2013)

NOT Suppressor of

Statement

Reference

srl^EY05931, Scer\GAL4^Mhc.PW is a non-suppressor of wing phenotype of Hsap\PABPN1^17ala.UAS, Scer\GAL4^Mhc.PW

(Chartier et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of srl^EY05931 significantly increases cell size (both nuclear area and cytoplasmic area) in clones in the fat body expressing Tor^TED.Scer\UAS under the control of Scer\GAL4^Act.PU.

Co-expression of srl^EY05931 suppresses the wing defects caused by expression of Tor^TED.Scer\UAS under the control of Scer\GAL4^Bx-MS1096.

Co-expression of srl^EY05931 suppresses the reduced cell size seen in cells in clones in the fat body expressing S6k^KQ.Scer\UAS under the control of Scer\GAL4^Act.PU.

Co-expression of srl^EY05931 almost completely rescues the bent upwards wing phenotype caused by expression of S6k^KQ.Scer\UAS under the control of Scer\GAL4^ap-md544.

Co-expression of srl^EY05931 can rescue normal cell size in approximately 11% of cells in clones expressing foxo^Scer\UAS.cPa under the control of Scer\GAL4^Act.PU in the fat body.

Co-expression of srl^EY05931 ameliorates the reduction in ommatidial number seen in the eyes of flies expressing foxo^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PU.

(Mukherjee and Duttaroy, 2013)

Xenogenetic Interactions

Statement

Reference

Expression of srl^EY05931 does not suppress the wing posture defects seen when Hsap\PABPN1^{17ala.Scer\UAS} is expressed under the control of Scer\GAL4^Mhc.PW.

(Chartier et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20009

y¹ w^67c23; P{EPgy2}srl^EY05931

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG9809^EY05931

PGC-1^EP

(Diop et al., 2015)

Spargel^EY05931

Srl^EY05931

(Weisz et al., 2024)

srl^EY05931

(Rojas-Ríos et al., 2024, Martin et al., 2021, Staats et al., 2019)

Name Synonyms

spargelEY05931

(Chartier et al., 2015)

Secondary FlyBase IDs

References (13)

Report Sections

Open Close