|Feature type||allele||Associated gene||Dmel\Trh|
|Also Known As||CG9122c01440|
|Map ( GBrowse )||
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
Trh[c01440] mutants exhibit an increase in neuronal arborization and varicosity number, compared to wild-type. Trh[c01440] mutant second instar larvae that are directly exposed to 10[-6]M 5-HT from 16 hours after egg laying to hatching, exhibit feeding behaviour that is indistinguishable from parental control flies, and a decrease in the complexity of serotonergic gut fibers projecting to the proventriculus. Hypersensitivity to 5-HTP is also rescued.
Larval feeding (measured by the number of mouth hook contractions in a yeast solution) is significantly affected by the decrease in neuronal 5-HT in Trh[c01440] mutants. This is unlikely to be due to aberrant motor control because body wall contractions (measured on an agar substrate) are unaffected. Heart rate in Trh[c01440] mutant white prepupae is significantly reduced relative to controls. Trh[c01440] mutants display an unusually strong aversion to the odorant nonanol, while showing a strong attraction to the odorant heptanol (as do controls). Female adult motor behaviour is significantly depressed by the decrease in neuronal 5-HT in Trh[c01440] mutants. Adult feeding behaviour is significantly decreased compared to controls, in both males and females. Embryonic survival of Trh[c01440] is enhanced relative to controls. The number of eclosing animals is decreased in Trh[c01440] mutants compared to controls, suggesting that Trh activity is critical, but no vital, during the larval and/or pupal stages. Adult survival does not require Trh activity for either female or male flies.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 4 )|
|Personal communication to FlyBase|