FB2025_01 , released February 20, 2025
Allele: Dmel\ScoxEY05333
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General Information
Symbol
Dmel\ScoxEY05333
Species
D. melanogaster
Name
FlyBase ID
FBal0160873
Feature type
allele
Associated gene
Dmel\Scox
Associated Insertion(s)
P{EPgy2}ScoxEY05333
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Porcelli et al., 2010)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}ScoxEY05333
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  retinal degeneration
      CEA
      (Huang et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ScoxEY05333 homozygous mutant clones in the eye have normal morphology at 1 day old and then show light-dependent retinal degeneration (at 10 days old, including loss of rhabdomeres), and ERG recordings show slow termination of the light response compared to wild type; precise excision of the ScoxEY05333 P-element rescues the phenotype.

      (Huang et al., 2015)

      ScoxSH1783/ScoxEY05333 trans-heterozygotes and ScoxEY05333/Df(2L)Exel7021 hemizygotes show developmental arrest at the start of the second larval instar. Many larvae survive about 15 days after hatching but appear severely dehydrated and their motility is extremely reduced.

      (Porcelli et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ScoxEY05333/ScoxSH1783 is rescued by Scox+t1.5

      (Porcelli et al., 2010)
      Comments

      A single copy of Scox+t1.5 rescues the lethality associated with ScoxEY05333/ScoxSH1783.

      (Porcelli et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Separable from: an independent lethal mutation.

      (Porcelli et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG8885EY05333
      ScoxEY05333
      (Kanellopoulos et al., 2020, Huang et al., 2015)
      l(2)EY05333
      (Porcelli et al., 2010)
      scox1
      (Porcelli et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)