homozygous adults show an increased resistance to ethanol as compared to controls: they show an increased time until sedation, despite an apparently normal tolerance development following daily exposure; they also show suppression of a normal ethanol-induced disinhibition, as shown by the virtual lack of inter-male courtship upon continual exposure.
homozygous and (to a lesser extent) heterozygous as well as DopEcRc02142
transheterozygous adults show resistance to ethanol-induced sedation: it takes significantly longer for them cease all movement upon ethanol exposure, although they begin to lose posture around the same time as controls. The ethanol absorption and metabolism of the mutants is normal. However, significantly fewer DopEcRc02142
mutants actually survive and recover from sedation.
Homozygotes reach adulthood and have no gross morphological defects.
The short- and long-latency thresholds of the giant-fiber pathway in heterozygous, homozygous and DopEcRc02142
flies is indistinguishable from that of controls. However, the refractory period is significantly reduced in homozygotes compared to controls and homozygotes and DopEcRc02142
flies show a delay in habituation of the giant fiber pathway.
Homozygous and DopEcRc02142
males lack 30-minute courtship memory in a courtship conditioning assay, although homozygotes show significant memory immediately after conditioning.
Unlike in wild type flies, DopEcRc02142
mutants do not show an increased sugar sensitive proboscis extension reflex (PER) in response to either L-Dopa feeding or 6 hours of wet starvation. The loss of response to L-Dopa is observed 48 hours after feeding, whereas the starvation response is observed at 6 hours, but is not seen after 24 hours.