FB2025_01 , released February 20, 2025
Allele: Dmel\kayEY12710
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General Information
Symbol
Dmel\kayEY12710
Species
D. melanogaster
Name
FlyBase ID
FBal0162157
Feature type
allele
Associated gene
Dmel\kay
Associated Insertion(s)
P{EPgy2}kayEY12710
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}kayEY12710
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show no significant difference in RP2 dendrite volume compared to controls.

      (Hartwig et al., 2008)

      Third instar larvae expressing kayEY12710 under the control of Scer\GAL4Pxn.PS have an increased number of sessile hemocytes. The number of hemocytes in circulation is also increased. The dorsal sessile hemocyte department is not disrupted. Sessile hemocytes do not accumulate along the dorsal vessel or spread through the cuticle. The lymph gland is enlarged. Hemocyte shape is normal.

      (Stofanko et al., 2008)

      Expression of kayEY12710 under the control of Scer\GAL4hs.2sev results in 40% of ommatidia with a symmetric R3/R4 arrangement, and 3% of ommatidia with inverted chirality.

      Overexpression of kayEY12710 under the control of Scer\GAL4Act in the R3 cell has no effect on ommatidial polarity. Overexpression of kayEY12710 under the control of Scer\GAL4Act in the R4 cell results in loss of R4 fate in 53.8% of cases.

      (Weber et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      kayEY12710, Scer\GAL4GMR.PF is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG15507EY12710
      fosEP<up>EY12710</up>
      (Weber et al., 2008)
      kay12710
      (Hartwig et al., 2008)
      kayEY12710
      (Feuillette et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)