FlyBase Allele Report: Dmel\POLDIP2[EY08866]

General Information

Symbol

Dmel\POLDIP2^EY08866

Species

D. melanogaster

Name

FlyBase ID

FBal0162487

Feature type

allele

Associated gene

Dmel\POLDIP2

Associated Insertion(s)

P{EPgy2}POLDIP2^EY08866

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypermorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypermorphic allele - molecular evidence

(Kim et al., 2015)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}POLDIP2^EY08866

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:5,468,005..5,468,005 [-]

(Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Kim et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Gene Disruption Project members, 2001-)

viable

(Gene Disruption Project members, 2001-)

Phenotype Manifest In

mitochondrial chromosome | spermatogenesis

(Wang et al., 2025)

mitochondrial chromosome | spermatogenesis (with POLDIP2^EMS-23)

(Wang et al., 2025)

mitochondrial chromosome | spermatogenesis (with POLDIP2^KO1)

(Wang et al., 2025)

spermatozoon

(Wang et al., 2025)

spermatozoon (with POLDIP2^EMS-23)

(Wang et al., 2025)

spermatozoon (with POLDIP2^KO1)

(Wang et al., 2025)

Detailed Description

Statement

Reference

Adult eyes have wild type morphology.

(Kim et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

POLDIP2^EY08866 is a suppressor of short lived phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Kim et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

POLDIP2^EY08866 is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Kim et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The decreased lifespan resulting from the expression of Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU is suppressed by POLDIP2^EY08866.

(Kim et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17500

y¹ w^67c23; P{EPgy2}POLDIP2^EY08866

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG12162^EY08866

(Kim et al., 2015)

POLDIP2^EY08866

poldip2^EY08866

(Wang et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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