FlyBase Allele Report: Dmel\tefu[atm-3]

General Information

Symbol

Dmel\tefu^atm-3

Species

D. melanogaster

Name

FlyBase ID

FBal0175415

Feature type

allele

Associated gene

Dmel\tefu

Associated Insertion(s)

Carried in Construct

Also Known As

atm³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Silva et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,240,062..15,240,062 [-]

Nucleotide change:

C15240062T

Amino acid change:

Q600term | tefu-PB

Reported amino acid change:

Q600term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator.

(Pedersen et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of ataxia telangiectasia

CEA with tefu^atm-6

(Silva et al., 2004)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

anaphase & condensed nuclear chromosome (with tefu^atm-6)

(Silva et al., 2004)

antenna | P-stage

(Silva et al., 2004)

chaeta | P-stage

(Silva et al., 2004)

chromosome, telomeric region (with tefu^atm-6)

(Silva et al., 2004)

chromosome | male | third instar larval stage

(Mengoli et al., 2014)

eye | P-stage

(Silva et al., 2004)

eye | somatic clone

(Hong and Choi, 2013)

larval brain | male | third instar larval stage

(Mengoli et al., 2014)

larval neuroblast | larval stage

(Hong and Choi, 2013)

leg | P-stage

(Silva et al., 2004)

metaphase & condensed nuclear chromosome (with tefu^atm-6)

(Silva et al., 2004)

wing | P-stage

(Silva et al., 2004)

Detailed Description

Statement

Reference

The brains of tefu^atm-3 homozygote male third instar larvae (treated with colchicine and hypotonic solution) show a significant increase in the frequency of chromosomal aberrations compared to wild-type.

(Mengoli et al., 2014)

Mosaic eyes produced by the EGUF/Hid method are reduced in size compared to wild type.

Neuroblasts in the brain of homozygous larvae show chronic spontaneous chromosome aberrations (12.5% fused chromosomal arms, 1.6% double-strand breaks).

(Hong and Choi, 2013)

Homozygous pupae have variable morphological defects affecting the antennae, eyes, bristles, wings and legs. tefu^atm-3/tefu^atm-6 larval neuroblasts show an extremely high rate of spontaneous chromosomal aberrations. The most frequent defects are telomere fusions (seen in more than 50% of metaphase figures). Both single- and double-telomere associations are seen, including sister and nonsister fusions of homologous chromosomes, as well as fusions between nonhomologous chromosomes. Acentric chromosome fragments are occasionally seen, as are chromosomal transpositions involving the loss of whole chromosome arms. Chromosomal bridges are often seen in anaphase figures.

(Silva et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

tefu^atm-3 has abnormal DNA repair | larval stage phenotype, enhanceable by Tctp^EY09182

(Hong and Choi, 2013)

tefu^atm-3 has abnormal cell cycle | larval stage phenotype, enhanceable by Tctp^EY09182

(Hong and Choi, 2013)

Suppressed by

Statement

Reference

tefu^atm-3 has visible | somatic clone phenotype, suppressible by Tctp^UAS.cHa/Scer\GAL4^ey.PH

(Hong and Choi, 2013)

NOT suppressed by

Statement

Reference

tefu^atm-3 has visible | somatic clone phenotype, non-suppressible by Tctp^E12V.UAS/Scer\GAL4^ey.PH

(Hong and Choi, 2013)

NOT Suppressor of

Statement

Reference

tefu^atm-3/tefu^atm-3 is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of Top2^suo3/Df(2L)Exel9043

(Mengoli et al., 2014)

Other

Statement

Reference

Tctp^h59/Tctp[+], tefu^atm-3 has abnormal developmental rate | dominant phenotype

(Hong and Choi, 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

tefu^atm-3 has chromosome | third instar larval stage | male phenotype, enhanceable by Top2^suo1/Top2^suo3

(Mengoli et al., 2014)

tefu^atm-3 has larval brain | third instar larval stage | male phenotype, enhanceable by Top2^suo1/Top2^suo3

(Mengoli et al., 2014)

Suppressed by

Statement

Reference

tefu^atm-3 has eye | somatic clone phenotype, suppressible by Tctp^UAS.cHa/Scer\GAL4^ey.PH

(Hong and Choi, 2013)

NOT suppressed by

Statement

Reference

tefu^atm-3 has eye | somatic clone phenotype, non-suppressible by Tctp^E12V.UAS/Scer\GAL4^ey.PH

(Hong and Choi, 2013)

Enhancer of

Statement

Reference

tefu^atm-3/tefu^atm-3 is an enhancer of larval brain | third instar larval stage | male phenotype of Top2^suo1/Top2^suo3

(Mengoli et al., 2014)

NOT Suppressor of

Statement

Reference

tefu^atm-3/tefu^atm-3 is a non-suppressor of larval brain | third instar larval stage phenotype of Top2^suo3/Df(2L)Exel9043

(Mengoli et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The increased frequency of chromosomal aberrations in third instar larval brain cells characteristic for Top2^suo3/Top2^suo1 and tefu^atm-3/tefu^atm-3 single mutant males is enhanced further in Top2^suo3/Top2^suo1;tefu^atm-3/tefu^atm-3 double mutants.

The low mitotic index observed in Top2^suo3/Df(2L)Exel9043 third instar larval brains cannot be rescued by combination with either mei-41^29D or tefu^atm-3/tefu^atm-3.

(Mengoli et al., 2014)

tefu^atm-3/Tctp^h59 double heterozygotes show a 2 day delay in the start of pupation compared to either wild-type controls or either single heterozygote.

Expression of Tctp^Scer\UAS.cHa under the control of Scer\GAL4^ey.PH strongly suppresses the reduced eye phenotype seen in tefu^atm-3 mosaic eyes produced by the EGUF/Hid method.

Expression of Tctp^{E12V.Scer\UAS} under the control of Scer\GAL4^ey.PH does not suppress the reduced eye phenotype seen in tefu^atm-3 mosaic eyes produced by the EGUF/Hid method.

Homozygosity for Tctp^EY09182 enhances the chromosome aberrations seen in brain neuroblasts of tefu^atm-3 larvae (18.0% fused chromosomal arms, 7.9% double-strand breaks).

(Hong and Choi, 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8625

w^*; P{neoFRT}82B tefu^atm-3 e¹/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

ATM³

(Rimkus and Wassarman, 2018, Petersen et al., 2013)

Atm³

(Lee et al., 2016)

atm³

(Jansen et al., 2024, Mengoli et al., 2014, Hong and Choi, 2013, Wells et al., 2006, Silva et al., 2004)

tefu³

(Mengoli et al., 2014)

tefu^atm-3

(Jansen et al., 2024, Li et al., 2021, Derive et al., 2015, Christensen et al., 2009.2.28, Christensen et al., 2008.4.15)

Name Synonyms

Secondary FlyBase IDs

References (13)

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