Allele Dmel\smo^{SD123.Scer\UAS.T:Zzzz\FLAG}

General Information
Symbol	Dmel\smo^{SD123.Scer\UAS.T:Zzzz\FLAG}	Species	D. melanogaster
Name		FlyBase ID	FBal0175475
Feature type	allele	Associated gene	Dmel\smo

Allele class
Mutagen	in vitro construct - site directed mutagenesis
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - site directed mutagenesis (Jia et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	smo^{Scer\UAS.J.T:Zzzz\FLAG} (Jia et al., 2004)
Nature of the lesion	Statement Reference Construct: Amino acid replacement: S670D. Amino acid replacement: S673D. Amino acid replacement: S667D. Amino acid replacement: S687D. Amino acid replacement: S680D. Amino acid replacement: S683D. Amino acid replacement: S740D. Amino acid replacement: S743D. Amino acid replacement: S746D. (Jia et al., 2004)
Carried in construct	P{UAS-smo.Fg.SD123} (Jia et al., 2004, Zhou et al., 2006, Molnar et al., 2007, Molnar et al., 2011)
Tagged with	T:Zzzz\FLAG (Jia et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	size defective, with Scer\GAL4^MD-638 (Molnar et al., 2011)
Phenotype Manifest In
	imaginal disc anterior compartment, with Scer\GAL4^MD-638 (Molnar et al., 2007) wing, with Scer\GAL4^MD-638 (Molnar et al., 2007) wing disc \| third instar larval stage, with Scer\GAL4^MD-638 (Molnar et al., 2011) wing vein L2, with Scer\GAL4^MD-638 (Molnar et al., 2007) wing vein L3, with Scer\GAL4^MD-638 (Molnar et al., 2007)
Detailed Description
	Statement Reference Wing discs overexpressing smo[SD123.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[MD-638] are overgrown. (Molnar et al., 2011) Expression of smo[SD123.Scer\UAS.T:Zzzz\FLAG] in the wing under the control of Scer\GAL4[MD-638] results in overgrowth of the anterior compartment of the wing and defects in the L3 and L2 veins. (Molnar et al., 2007)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	smo^{SD123.Scer\UAS.T:Zzzz\FLAG}
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Molnar et al., 2011, PLoS Genet. 7(3): e1001335 Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling. [FBrf0213301] Molnar et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104(19): 7963--7968 The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. [FBrf0202089] Zhou et al., 2006, Genetics 173(4): 2049--2062 The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. [FBrf0193965] Jia et al., 2004, Nature 432(7020): 1045--1050 Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. [FBrf0182981]

Allele Dmel\smoSD123.Scer\UAS.T:Zzzz\FLAG

Allele Dmel\smo^{SD123.Scer\UAS.T:Zzzz\FLAG}