FlyBase Allele Report: Dmel\scrib[5]

General Information

Symbol

Dmel\scrib⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0175526

Feature type

allele

Associated gene

Dmel\scrib

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | larval stage (with scrib⁶⁷³)

(Huang et al., 2023)

abnormal planar polarity | somatic clone

(Courbard et al., 2009)

viable (with scrib¹)

(Brumby et al., 2004)

viable (with scrib^jB709)

(Brumby et al., 2004)

visible (with scrib¹)

(Brumby et al., 2004)

visible (with scrib^jB709)

(Brumby et al., 2004)

Phenotype Manifest In

adult thorax (with scrib¹)

(Brumby et al., 2004)

adult thorax (with scrib^jB709)

(Brumby et al., 2004)

chaeta (with scrib¹)

(Brumby et al., 2004)

chaeta (with scrib^jB709)

(Brumby et al., 2004)

eye (with scrib¹)

(Brumby et al., 2004)

eye (with scrib^jB709)

(Brumby et al., 2004)

eye | somatic clone

(Courbard et al., 2009)

eye photoreceptor cell | somatic clone

(Courbard et al., 2009)

ommatidium | somatic clone

(Courbard et al., 2009)

rhabdomere | somatic clone

(Courbard et al., 2009)

wing disc | larval stage (with scrib⁶⁷³)

(Huang et al., 2023)

wing hair | somatic clone

(Courbard et al., 2009)

Detailed Description

Statement

Reference

Only small homozygous clones are generally recovered in the adult eye. Symmetrical R3/R3 ommatidia are occasionally seen in these clones, as well as rotation and chirality defects in ommatidia. Rare, larger clones in the eye result in significant abnormalities in ommatidial architecture, with fused photoreceptors, malformed rhabdomeres and loss of photoreceptors.

Analysis of mosaic ommatidia indicates that when the precursor for photoreceptor cell R3 is wild type and the R4 precursor is mutant, 73% of the mosaic clusters have chirality defects (31.7% show inverted chirality and 41.3% are symmetrical), whereas when the R3 precursor is mutant and the R4 precursor is wild type, most of the mosaic ommatidia have normal chirality.

Homozygous clones in the wing results in planar cell polarity defects, apparent as "waves" and "whorls" of wing hair orientation. A multiple wing hair phenotype is also seen.

(Courbard et al., 2009)

scrib¹/scrib⁵ and scrib^jB709/scrib⁵ adults show defects in thorax closure.

(Brumby et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Eb1^42S11, scrib¹/scrib⁵ has partially lethal phenotype