Allele Dmel\nerfin-1^Scer\UAS.cKa

General Information
Symbol	Dmel\nerfin-1^Scer\UAS.cKa	Species	D. melanogaster
Name		FlyBase ID	FBal0175566
Feature type	allele	Associated gene	Dmel\nerfin-1

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Kuzin et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS sequences drive expression of nerfin-1. (Kuzin et al., 2005)
Carried in construct	P{UAS-nerfin-1} (Kuzin et al., 2005, Hartl et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	viable, with Scer\GAL4^twi.PB (Kuzin et al., 2005)
Phenotype Manifest In
	intermediate longitudinal fascicle, with Scer\GAL4^elav-C155 (Kuzin et al., 2005) lateral longitudinal fascicle, with Scer\GAL4^elav-C155 (Kuzin et al., 2005) medial longitudinal fascicle, with Scer\GAL4^elav-C155 (Kuzin et al., 2005)
Detailed Description
	Statement Reference Expression of nerfin-1[Scer\UAS.cKa] under the control of Scer\GAL4[Act.PU] the eyFLP technique does not result in an altered targeting pattern of CO[[2]] neurons. (Hartl et al., 2011) When nerfin-1^Scer\UAS.cKa is driven by Scer\GAL4^cas-3921, Scer\GAL4^pros.PMG or Scer\GAL4^sca-537.4 no alterations in neuronal or glial development are seen. Axon fascicle patterning is also not affected. When nerfin-1^Scer\UAS.cKa is driven by Scer\GAL4^twi.PB, there is no detectable effect on muscle development or embryonic viability. When nerfin-1^Scer\UAS.cKa is driven by Scer\GAL4^elav-C155 embryos exhibit multiple defects in axon scaffolding throughout the CNS. The development of certain longitudinal connectives is affected. The intermediate and lateral longitudinal fascicles defasciculate, as does the medial longitudinal fascicles, but to a lesser degree. (Kuzin et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	Scer\GAL4^elav-C155/nerfin-1^Scer\UAS.cKa partially rescues nerfin-1⁵⁴ (Kuzin et al., 2005)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	nerfin-1^Scer\UAS.cKa
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Hartl et al., 2011, J. Neurosci. 31(44): 15660--15673 A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation. [FBrf0216631] Kuzin et al., 2005, Dev. Biol. 277(2): 347--365 Nerfin-1 is required for early axon guidance decisions in the developing Drosophila CNS. [FBrf0183075]

Allele Dmel\nerfin-1Scer\UAS.cKa

Allele Dmel\nerfin-1^Scer\UAS.cKa