FB2025_02 , released April 17, 2025
Allele: Dmel\nejKIX.UAS
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General Information
Symbol
Dmel\nejKIX.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0175572
Feature type
allele
Associated gene
Dmel\nej
Associated Insertion(s)
Carried in Construct
P{UAS-nej.KIX}
Key Links
Transgenic product class
inframe_deletion
(Kumar et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kumar et al., 2004)
Mutagen
in vitro construct
(Kumar et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-nej.KIX}
Cytology
Description

UASt regulatory sequences drive expression of a deleted form of nej, consisting of an ATG followed by nej amino acids 800-1090.

(Kumar et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
nej
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.cUa
      (Cutler et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of nejKIX.Scer\UAS under the control of Scer\GAL4GMR.PU does not result in any obvious eye phenotypes in adults.

      (Cutler et al., 2015)

      Expression of nejKIX.Scer\UAS under the control of Scer\GAL4hs.2sev can result in the transformation of the small inner R7 photoreceptor into a large outer photoreceptor. The very mild rough eye phenotype caused by expression of nejKIX.Scer\UAS under the control of Scer\GAL4GMR.PF is suppressed if the flies also carry nej3/+.

      (Kumar et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of nejKIX.Scer\UAS partially rescues the small eye and lens fusion phenotype seen in adult flies expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU. Co-expression of nejKIX.Scer\UAS partially suppresses the increased cell death observed in third instar eye discs of flies expressing Hsap\APPAβ42.Scer\UAS.cUa under the control of Scer\GAL4GMR.PU.

      (Cutler et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nejKIX.Scer\UAS
      nejKIX.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)