FlyBase Allele Report: Dmel\coro[ex11]

General Information

Symbol

Dmel\coro^ex11

Species

D. melanogaster

Name

FlyBase ID

FBal0175730

Feature type

allele

Associated gene

Dmel\coro

Associated Insertion(s)

P{GAL4-Δex11}coro^ex11

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Bharathi et al., 2004)

Mutagen

P-element activity

(Bharathi et al., 2004)

Progenitor genotype

coro⁴⁰⁹

(Bharathi et al., 2004)

Associated Insertion(s)

P{GAL4-Δex11}coro^ex11

Cytology

Description

Imprecise excision of the P{GAL4} element, resulting in an internal deletion of the element.

(Bharathi et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Bharathi et al., 2004)

lethal - all die before end of pupal stage | recessive

(Bharathi et al., 2004)

some die during pupal stage | recessive

(Bharathi et al., 2004)

viable

(Bharathi et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous coro^ex11 mutants are lethal at early to late pupal stages, with 10% viability. Adult legs of coro^ex11 flies appear to be short and thick. Duplication of sex combs in coro^ex11 flies indicates ventralization of legs. Both anterior and posterior adult wing margins exhibit thickening of veins (with Delta vein phenotypes at the most distal regions) and small necrotic patches. Homozygous wing discs are marginally smaller than normal. Approximately 30% of homozygous wing discs are not properly joined along the AP boundary. A rough eye phenotype is exhibited in coro^ex11 flies. Eyes of coro^ex11 flies exhibit loss and fusion of ommatidia and loss of inter-ommatidial bristles. More severely, total loss of eyes is observed in coro^ex11 flies. The ovary in coro^ex11 flies is small and devoid of any oocytes. coro^ex6/coro^ex11 pharate adults often show total loss of one or more legs. A small number of coro^ex6/coro^ex11 wing discs show a deep cleft along either the AP or DV boundary. Wing discs are very small and often show reduction of the wing pouch area. Individual peripodial cells appear normal and the peripodial membrane does not show any defect.

(Bharathi et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

coro^ex11 has lethal | larval stage phenotype, enhanceable by Scer\GAL4^dpp.blk1/Syx1A^DN.UAS

(Bharathi et al., 2004)

Enhancer of

Statement

Reference

Scer\GAL4^dpp.blk1, coro[+], coro^ex11 is an enhancer of visible phenotype of tkv^{Q253D.UAS.cNb}

(Bharathi et al., 2004)

Other

Statement

Reference

Scer\GAL4^dpp.blk1, coro^ex11, tkv^{Q253D.UAS.cNb} has visible phenotype

(Bharathi et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

coro^ex11 has anterior-posterior compartment boundary of the wing disc phenotype, enhanceable by Scer\GAL4^dpp.blk1/Syx1A^DN.UAS

(Bharathi et al., 2004)

Suppressed by

Statement

Reference

coro^ex6/coro^ex11 has dorsal mesothoracic disc & cytoskeleton phenotype, suppressible by dpp^UAS.T.EGFP/Scer\GAL4^dpp.blk1

(Bharathi et al., 2004)

Enhancer of

Statement

Reference

Scer\GAL4^dpp.blk1, coro[+], coro^ex11 is an enhancer of anterior-posterior compartment boundary of the wing disc phenotype of tkv^{Q253D.UAS.cNb}

(Bharathi et al., 2004)

Other

Statement

Reference

Scer\GAL4^dpp.blk1, coro^ex11, tkv^{Q253D.UAS.cNb} has anterior-posterior compartment boundary of the wing blade phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro^ex11, dpp^UAS.T.EGFP has wing disc phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro^ex6/coro^ex11, dpp^UAS.T.EGFP has wing disc phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro^ex11, dpp^UAS.T.EGFP has dorsal mesothoracic disc & cytoskeleton phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro[+]/coro^ex11, dpp^UAS.T.EGFP has wing disc phenotype

(Bharathi et al., 2004)

Scer\GAL4^dpp.blk1, coro[+]/coro^ex11, tkv^{Q253D.UAS.cNb} has anterior-posterior compartment boundary of the wing disc phenotype

(Bharathi et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Discs overexpressing dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.blk1 in coro^ex11 homozygous or heterozygous mutants or coro^ex6/coro^ex11 transheterozygous mutants are much larger than wild-type discs expressing dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.blk1. In coro^ex6/coro^ex11 mutants, a partial rescue of the actin cytoskeleton and apicobasal polarity is seen in wing discs overexpressing dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^dpp.blk1. Overexpression of tkv^{Q253D.Scer\UAS.cNb} under the control of Scer\GAL4^dpp.blk1 in coro^ex11 heterozygous backgrounds causes a severe cleft phenotype with 85% penetrance along the AP boundary of the wing disc. Enhancement is more pronounced in adult wing blades. Overexpression of Syx1A^DN.Scer\UAS driven by Scer\GAL4^dpp.blk1 enhances lethality in the coro^ex11 homozygous background. Overexpression of Syx1A^DN.Scer\UAS driven by Scer\GAL4^dpp.blk1 in coro^ex11 mutants causes higher incidences of cleft formation along the AP boundary of the wing disc.

(Bharathi et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

91348

w¹¹¹⁸; P{GAL4-Δex11}coro^ex11/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

coro^ex11

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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