FB2025_01 , released February 20, 2025
Allele: Dmel\btszJ5-2
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General Information
Symbol
Dmel\btszJ5-2
Species
D. melanogaster
Name
FlyBase ID
FBal0175741
Feature type
allele
Associated gene
Dmel\btsz
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Serano and Rubin, 2003)
Progenitor genotype
btszEP3567
(Serano and Rubin, 2003)
Cytology
Description

Corresponds to a frame-shift mutation that introduces a stop codon at amino acid 390, which leads to a truncation in btsz0 and btsz2, and probably the absence of btsz3 isoform.

(Pilot et al., 2006)

Imprecise excision of P{EP}btszEP3567 has resulted in a frameshift predicted to truncate the btsz2 isoform protein from 2,645 aa to 393 aa. Isoform 2 = GenBank:AY229970 ; exons 8 + 10-15.

(Serano and Rubin, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At stage 14, the epidermis in the region where the salivary gland placodal cells were located previously is disrupted and lost.

      (Maybeck and Röper, 2009)

      Approximately 46% of btszK13-4/btszJ5-2 embryos exhibit epithelial defects during gastrulation.

      btszJ5-2 germ-line clones do not produce eggs and are lethal.

      (Pilot et al., 2006)

      Only 70% (n = 654) of btszJ5-2 homozygous larvae survive to the third-instar stage, but they appear normal with regards to feeding and movement. Eclosion of btszJ5-2 homozygous adults is delayed 2-3 days compared to wild-type siblings. The resulting adults are 77% the weight and have 79% the wing area of their heterozygous siblings. Examination of wing hair density in these flies reveals a reduction in both cell size and cell number. There are no differences in ommatidium of photoreceptor size between wild-type cells and those that belong to btszJ5-2 homozygous somatic clones in the eye.

      (Serano and Rubin, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      btszJ5-2
      (Tsarouhas et al., 2023, Maybeck and Röper, 2009, Pilot, 2006, Pilot et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)