Allele Dmel\Pen^{-UTR.Scer\UAS.P\T}

General Information
Symbol	Dmel\Pen^{-UTR.Scer\UAS.P\T}	Species	D. melanogaster
Name		FlyBase ID	FBal0176053
Feature type	allele	Associated gene	Dmel\Pen

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Mason et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of the Pen ORF (no UTRs) is under the control of Scer\UAS and P\T promoter sequences. (Mason et al., 2003)
Carried in construct	P{UASp-Pen.-UTR} (Mason et al., 2003, Ratan et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Pen^{-UTR.Scer\UAS.P\T}/Scer\GAL4^αTub84B.PL is a suppressor \| partially of lethal \| larval stage phenotype of Kap-α3^17-7/Kap-α3^D93 (Mason et al., 2003) Pen^{-UTR.Scer\UAS.P\T}/Scer\GAL4^αTub84B.PL is a suppressor \| partially of lethal \| larval stage phenotype of Kap-α3^D93 (Mason et al., 2003) Scer\GAL4^Act5C.PI, Scer\GAL4^Act5C.PI, Pen^{-UTR.Scer\UAS.P\T} is a suppressor \| partially of lethal \| larval stage phenotype of Kap-α3^17-7/Kap-α3^D93 (Mason et al., 2003) Scer\GAL4^Act5C.PI, Scer\GAL4^Act5C.PI, Pen^{-UTR.Scer\UAS.P\T} is a suppressor \| partially of lethal \| larval stage phenotype of Kap-α3^D93 (Mason et al., 2003)
Phenotype Manifest In
NOT Suppressor of
Statement Reference Pen^{-UTR.Scer\UAS.P\T}/Scer\GAL4^ey.PH is a non-suppressor of eye \| somatic clone phenotype of Kap-α3^D93 (Mason et al., 2003) Pen^{-UTR.Scer\UAS.P\T}/Scer\GAL4^ey.PH is a non-suppressor of ommatidium \| somatic clone phenotype of Kap-α3^D93 (Mason et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Expression of Pen[-UTR.Scer\UAS.P\T] under the control of Scer\GAL4[Act5C.PI] does not restore fertility in Df(3L)α1S1 males. Expression of Pen[-UTR.Scer\UAS.P\T] under the control of Scer\GAL4[nos.UTR.T:Hsim\VP16] does not restore fertility or fecundity in Df(3L)α1S1 females. (Ratan et al., 2008) Pen^{-UTR.Scer\UAS.P\T} driven by Scer\GAL4^Act5C.PI or Scer\GAL4^αTub84B.PL can weakly suppress the first instar larval lethality of Kap-α3^D93 homozygotes or Kap-α3^D93/Kap-α3^17-7 animals. Many larvae survive to second or early third instar, and occasionally animals survive to pupation (or even pharate adult stage in the case of the heterozygotes). Pen^{-UTR.Scer\UAS.P\T}; Scer\GAL4^ey.PH fails to suppress the eye phenotypes due to Kap-α3^D93 somatic clones. (Mason et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Pen^{-UTR.Scer\UAS.P\T}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Ratan et al., 2008, Genetics 178(2): 839--850 Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis. [FBrf0204254] Mason et al., 2003, Genetics 165(4): 1943--1958 The Drosophila melanogaster importin alpha3 locus encodes an essential gene required for the development of both larval and adult tissues. [FBrf0167653]

Allele Dmel\Pen-UTR.Scer\UAS.P\T

Allele Dmel\Pen^{-UTR.Scer\UAS.P\T}