FB2025_01 , released February 20, 2025
Allele: Mmus\Tshz3UAS.Tag:MYC
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General Information
Symbol
Mmus\Tshz3UAS.Tag:MYC
Species
M. musculus
Name
FlyBase ID
FBal0176076
Feature type
allele
Associated gene
Mmus\Tshz3
Associated Insertion(s)
Carried in Construct
P{UAS-Zfp537.MYC}
Transgenic product class
cDNA
(Manfroid et al., 2004)
wild_type
(Manfroid et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Manfroid et al., 2004)
wild_type
(Manfroid et al., 2004)
Mutagen
in vitro construct
(Manfroid et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Zfp537.MYC}
Cytology
Description

Expression of Mmus\Tshz3 cDNA (Genbank: AY063491) in which the ORF is fused in frame to the epitope tag Tag:MYC, is under the control of UASt sequences.

(Manfroid et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Tshz3
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Changes in cuticle pattern indicate that in Mmus\Zfp537Scer\UAS.T:Hsap\MYC; Scer\GAL469B embryos, the labial segment is transformed to T1 and the antennal and maxillary head segments are transformed towards a trunk identity in that they develop denticles and naked cuticle. About half of Mmus\Zfp537Scer\UAS.T:Hsap\MYC; Scer\GAL4dpp.blk1 flies have an ectopic eye ventral to one or both of their eyes, whereas about a third of Mmus\Zfp537Scer\UAS.T:Hsap\MYC; Scer\GAL4ey.PH flies have no eyes at all.

      (Manfroid et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      At 22 degrees C, the presence of Mmus\Zfp537Scer\UAS.T:Hsap\MYC and Scer\GAL469B results in partial rescue of the T1 segment and trunk cuticle phenotypes of tsh8/tsh8 embryos. All these larvae show significant but incomplete rescue of the T1 denticle belt phenotype but none of them displays beard-specific denticles. The size of the naked cuticle bands in the trunk appears normal. At 29 degrees C this rescue is more complete.

      (Manfroid et al., 2004)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mmus\Tshz3Scer\UAS.T:Hsap\MYC
      Mmus\Tshz3UAS.Tag:MYC
      Mmus\Zfp537Scer\UAS.T:Hsap\MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)