A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Allele Dmel\Drp11

General Information
SymbolDmel\Drp11SpeciesD. melanogaster
NameFlyBase IDFBal0176235
Feature typealleleAssociated geneDmel\Drp1
Allele class
Mutagen
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Description
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FB2012_01
FB2011_10
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Mutation identified by sequence analysis.
(Ly, 2005.3.2)
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal (with Drp12)
(Ly, 2005.3.2)
neurophysiology defective
(Ly, 2005.3.2)
hide Phenotype Manifest In
mitochondrion (with Drp12)
(Rival et al., 2011, Rival et al., 2011)
mitochondrion & bouton (with Drp12)
(Verstreken et al., 2005)
mitochondrion & larval salivary gland
(Verstreken et al., 2005)
hide Detailed Description
Statement
Reference
In Drp1[1]/Drp1[2] mutant adult flight muscles, the mitochondria are enlarged (being round in shape) and fewer in number compared to wild type but contain intact internal structures.
(Rival et al., 2011)
Drp1[1]/Drp1[2] cells contain fewer mitochondria per cell than wild type and mitochondrial morphology is abnormal.
(Rival et al., 2011)
Shows defects in neurotransmitter release.
(Ly, 2005.3.2)
Homozygous third instar salivary gland cells show clustering of mitochondria. Mitochondrial number per bouton is reduced at Drp1[1]/Drp1[2] neuromuscular junctions.
(Verstreken et al., 2005)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideOther
Statement
Reference
Df(3L)Pmi-PGRP-LD, Drp12/Drp11 has lethal phenotype
(Rival et al., 2011, Rival et al., 2011)
hide Phenotype Manifest In
hideSuppressed by
Statement
Reference
Drp12/Drp11 has mitochondrion phenotype, suppressible by MarfmiRNA.UTR.Scer\UAS/Scer\GAL4elav.PU
(Rival et al., 2011)
Drp12/Drp11 has mitochondrion phenotype, suppressible by Scer\GAL4elav.PU/MarfmiRNA.CDS.Scer\UAS
(Rival et al., 2011)
Drp12/Drp11 has mitochondrion phenotype, suppressible by Scer\GAL4elav.PU/opa1-likemiRNA.CDS.Scer\UAS
(Rival et al., 2011)
hideNOT suppressed by
Statement
Reference
Drp12/Drp11 has mitochondrion phenotype, non-suppressible by Scer\GAL4elav.PU/PmiScer\UAS.cRa
(Rival et al., 2011)
hide Additional Comments
hide Genetic Interactions
Statement
Reference
Expression of either Marf[miRNA.CDS.Scer\UAS], Marf[miRNA.UTR.Scer\UAS] or opa1-like[miRNA.CDS.Scer\UAS] under the control of Scer\GAL4[elav.PU] is sufficient to restore a normal filamentous mitochondrial network in Drp1[1]/Drp1[2] flies. Expression of Pmi[Scer\UAS.cRa] under the control of Scer\GAL4[elav.PU] does not rescue mitochondrial morphology in Drp1[1]/Drp1[2] flies.
(Rival et al., 2011)
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Fails to complement
Drp12
(Ly, 2005.3.2)
Drp1H7
(Ly, 2005.3.2)
Drp1KG03815
(Ly, 2005.3.2, Verstreken et al., 2005)
Drp1T26
(Ly, 2005.3.2)
Rescued by
Drp12/Drp11 is rescued by Drp1+t9.4
(Verstreken et al., 2005)
Drp12/Drp11 is rescued by Drp1Scer\UAS.cDa/Scer\GAL4elav.PU
(Rival et al., 2011)
Drp12/Drp11 is rescued by Drp1T:Zzzz\FLAG,T:Zzzz\TC,T:Ivir\HA1
(Verstreken et al., 2005)
Comments
Expression of Drp1[Scer\UAS.cDa] under the control of Scer\GAL4[elav.PU] rescues mitochondrial morphology in Drp1[1]/Drp1[2] flies.
(Rival et al., 2011)
Lethality of Drp11/Drp12 rescued by a genomic rescue construct spanning the 'CG3210' annotation.
(Ly, 2005.3.2)
hide Stocks ( 1 )
Bloomington
24885
yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{Car20y}25F Drp11 P{neoFRT}40A/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7
hide Notes on Origin
Discoverer
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym
drp11
(Ly, 2005.3.2, Rival et al., 2011, Rival et al., 2011, Verstreken et al., 2005, Deng et al., 2008)
Drp11
 
frat1
(Ly, 2005.3.2, Verstreken et al., 2005)
Name Synonym
Secondary FlyBase IDs
hide References ( 5 )
Research paper
Rival et al., 2011, EMBO Rep. 12(3): 223--230
Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways. [FBrf0213174]
Deng et al., 2008, Proc. Natl. Acad. Sci. U.S.A. 105(38): 14503--14508
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. [FBrf0206104]
Verstreken et al., 2005, Neuron 47(3): 365--378
Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. [FBrf0188182]
Supplementary material
Rival et al., 2011, EMBO Rep. 12(3):
Supplementary material. [FBrf0213707]
Personal communication to FlyBase
Ly, 2005.3.2, Helping FlyBase: ADRC-50399.
Helping FlyBase: ADRC-50399. [FBrf0183137]