Allele Dmel\Atg8a^{hs.T:Avic\GFP}

General Information
Symbol	Dmel\Atg8a^{hs.T:Avic\GFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0176388
Feature type	allele	Associated gene	Dmel\Atg8a

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Scott et al., 2004) in vitro construct - regulatory fusion (Scott et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Carried in construct	P{hs-Atg8a.GFP} (Berry and Baehrecke, 2007, Scott et al., 2004, Tang et al., 2011, Juhász et al., 2007, Scott et al., 2007, Juhász et al., 2008, McPhee et al., 2010, Csikós et al., 2009)
Tagged with	T:Avic\GFP (Scott et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Atg8a^{hs.T:Avic\GFP} rescues Atg8a^KG07569 (Berry and Baehrecke, 2007, Scott et al., 2007)
Comments	Expression of Atg8a^{hs.T:Avic\GFP} using heat shock rescues the phenotype of persistence of salivary gland tissue that is seen at 24 hours hours after puparium formation in Atg8a^KG07569 animals. (Berry and Baehrecke, 2007) Starvation-induced autophagy is restored in Atg8a[KG07569] animals that are also expressing Atg8a[hs.T:Avic\GFP]. (Scott et al., 2007)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Atg8a^{hs.T:Avic\GFP}
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Tang et al., 2011, EMBO J. 30(4): 636--651 Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy. [FBrf0213047] McPhee et al., 2010, Nature 465(7301): 1093--1096 Activation of autophagy during cell death requires the engulfment receptor Draper. [FBrf0211145] Csikós et al., 2009, Autophagy 5(5): 636--648 A novel role for the Drosophila epsin (lqf): involvement in autophagy. [FBrf0215334] Juhász et al., 2008, J. Cell Biol. 181(4): 655--666 The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. [FBrf0204844] Berry and Baehrecke, 2007, Cell 131(6): 1137--1148 Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. [FBrf0200408] Juhász et al., 2007, Genes Dev. 21(23): 3061--3066 Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. [FBrf0201603] Scott et al., 2004, Dev. Cell 7(2): 167--178 Role and regulation of starvation-induced autophagy in the Drosophila fat body. [FBrf0180117]
Supplementary material	Scott et al., 2007, Curr. Biol. 17(1): Supplemental Data. [FBrf0208086]

Allele Dmel\Atg8ahs.T:Avic\GFP

Allele Dmel\Atg8a^{hs.T:Avic\GFP}