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General Information
Symbol
Dmel\Ada2b1
Species
D. melanogaster
Name
FlyBase ID
FBal0176420
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Imprecise excision of the P{EP} element, resulting in a 1077bp deletion that encompasses the Ada2b transcription start site and entire first exon.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EP} element, resulting in a 1077bp deletion that encompasses the Ada2b transcription start site and entire first exon (including the translation start codon).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Follicle border cell clusters either fully clonal or mosaic for Ada2b1/Ada2b1 show severely delayed migration.

Ada2b1 mosaic adults in which the eyes are homozygous for Sf3b5EY12579, while the rest of the body is heterozygous (generated by the EGUF method) show normal eye size compared to controls.

In Ada2b1 larvae, many R2-R5 axons fail to terminate in the lamina and instead project into the medulla. A reduced number of glial cells are present along the lamina compared to wild type and slight increases in the number of glial cells are present at the margins of the lamina regions.

Homozygotes die during early pupal stages, mostly before head eversion occurs, without any other gross morphological abnormalities. No eggs are obtained from females containing homozygous germline clones.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Other
Phenotype Manifest In
NOT suppressed by
Enhancer of
Statement
Reference

Ada2b[+]/Ada2b1 is an enhancer of wing margin phenotype of mamg2.1

NOT Enhancer of
Statement
Reference

Ada2b[+]/Ada2b1 is a non-enhancer of wing blade phenotype of Nnd-1

NOT Suppressor of
Statement
Reference

Ada2b[+]/Ada2b1 is a non-suppressor of wing vein L4 phenotype of NAx-E2

Other
Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for Ada2b1 increases the number of wing margin nicks seen in mamg2.1 heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (11)