Allele Dmel\vih^a.cMa

General Information
Symbol	Dmel\vih^a.cMa	Species	D. melanogaster
Name	antisense construct a of Mathe	FlyBase ID	FBal0177244
Feature type	allele	Associated gene	Dmel\vih

Allele class
Mutagen	in vitro construct - RNAi
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - RNAi (Mathe et al., 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Template corresponding to vih sequences, in antisense orientation. (Mathe et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	mitosis & nuclear chromosome, with vih^cMa (Mathe et al., 2004) spindle, with vih^cMa (Mathe et al., 2004)
Detailed Description
	Statement Reference Cells treated with vih dsRNA (produced by annealing vih^cMa and vih^a.cMa ssRNAs) show spindle defects, and the mitotic spindle never shows the prominent lengthening as normally occurs in anaphase. The defects include chromosomes scattered throughout spindles that usually just have a single centrosome and metaphase spindles which have chromosomes in the equatorial region, but are significantly shorter than the metaphase spindles of control cells. (Mathe et al., 2004)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Single stranded RNA has been synthesised from the template, annealed with vih^cMa ssRNA to produce dsRNA, and used to treat cells to study the phenotypic consequences of dsRNA interference (RNAi) of the vih gene. (Mathe et al., 2004)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	vih^a.cMa
Name Synonym	antisense construct a of Mathe (Mathe et al., 2004)
Secondary FlyBase IDs

References ( 1 )
Research paper	Mathe et al., 2004, Curr. Biol. 14(19): 1723--1733 The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. [FBrf0180066]

Allele Dmel\viha.cMa

Allele Dmel\vih^a.cMa