A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\vih1

General Information
SymbolDmel\vih1SpeciesD. melanogaster
NameFlyBase IDFBal0177248
Feature typealleleAssociated geneDmel\vih
Allele classhypomorphic allele - genetic evidence
Mutagen
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
atom feed
FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
hypomorphic allele - genetic evidence
(Mathe et al., 2004)
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
P{lacW} insertion in the 5' UTR.
(Mathe et al., 2004)
Caused by insertion
P{lacW}vih1
(Mathe et al., 2004)
Cytology
hide Phenotypic Data
hide Phenotypic Class
lethal | embryonic stage | maternal effect | recessive
(Mathe et al., 2004)
lethal | partially | pharate adult stage | recessive
(Mathe et al., 2004)
mitotic cell cycle defective
(Mathe et al., 2004)
hide Phenotype Manifest In
mitosis & nuclear chromosome
(Mathe et al., 2004)
mitosis & nuclear chromosome | maternal effect
(Mathe et al., 2004)
spindle | maternal effect
(Mathe et al., 2004)
hide Detailed Description
Statement
Reference
Approximately 20% of mutants die as pharate adults. The mitotic index and proportion of cells at different phases of the mitotic cycle in the brains of homozygous larvae are not significantly different from those of wild type. However, the mutant brains have aberrant mitotic figures in which the chromosomes are scattered apparently randomly through the cell, and there is a significant increase in polyploid mitotic figures compared to wild type. The proportion of these defects are increased in hemizygous larvae compared to homozygous larvae. The mitotic chromosomes are highly condensed in metaphase and anaphase in vih1 larvae. Spindle poles that lack centrosomes are seen and they are characteristically broad. Homozygous and hemizygous females produce syncytial embryos that fail to develop as a result of mitotic defects; the embryos rarely develop beyond the third nuclear division cycle, and mitotic figures have abnormal mitotic spindles and frequently have a polyploid complement of chromosomes.
(Mathe et al., 2004)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hide Phenotype Manifest In
hide Additional Comments
hide Genetic Interactions
Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Rescued by
vih1 is rescued by vihScer\UAS.P\T.cMa/Scer\GAL4mat.αTub67C.T:Hsim\VP16
(Mathe et al., 2004)
vih1 is rescued by vihUbi-p63E.PM
(Mathe et al., 2004)
Not rescued by
vih1 is not rescued by vihmD1.Scer\UAS.P\T/Scer\GAL4mat.αTub67C.T:Hsim\VP16
(Mathe et al., 2004)
vih1 is not rescued by vihmD1D2.Scer\UAS.P\T.T:Zzzz\His6/Scer\GAL4mat.αTub67C.T:Hsim\VP16
(Mathe et al., 2004)
vih1 is not rescued by vihmD2.Scer\UAS.P\T/Scer\GAL4mat.αTub67C.T:Hsim\VP16
(Mathe et al., 2004)
Comments
hide Stocks ( 0 )
hide Notes on Origin
Discoverer
hide Comments
Excision of the P{lacW} element can revert the zygotic semilethal and maternal effect lethal phenotypes.
(Mathe et al., 2004)
hide External Crossreferences & Linkouts
Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym
vih1
 
Name Synonym
Secondary FlyBase IDs
hide References ( 1 )
Research paper
Mathe et al., 2004, Curr. Biol. 14(19): 1723--1733
The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation. [FBrf0180066]