Allele Dmel\vas^{Δ617.T:Avic\GFP-EGFP}

General Information
Symbol	Dmel\vas^{Δ617.T:Avic\GFP-EGFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0177265
Feature type	allele	Associated gene	Dmel\vas
Also Known As	vas^Δ617

Allele class
Mutagen	in vitro construct - site directed mutagenesis
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - site directed mutagenesis (Johnstone and Lasko, 2004)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	vas^{T:Avic\GFP-EGFP} (Johnstone and Lasko, 2004)
Nature of the lesion	Statement Reference Construct: Identical to vas^{T:Avic\GFP-EGFP}, apart from the deletion of P617. (Johnstone and Lasko, 2004)
Carried in construct	P{vas.Δ617.EGFP} (Johnstone and Lasko, 2004, Liu et al., 2009, Pek and Kai, 2011)
Tagged with	T:Avic\GFP^EGFP (Johnstone and Lasko, 2004)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescues	vas^{Δ617.T:Avic\GFP-EGFP} partially rescues vas^PH165 (Johnstone and Lasko, 2004)
Comments	The mitotic delay which is seen in the germline stem cells and cystoblasts of vas[PH165] ovaries is rescued by vas[Δ617.T:Avic\GFP-EGFP]. (Pek and Kai, 2011) vas^{Δ617.T:Avic\GFP-EGFP} does not rescue the oogenesis defects or the maternal effect elimination of pole cells in the embryo due to vas^PH165. However, posterior segmentation defects are partly rescued, and embryos hatch into viable larvae. (Johnstone and Lasko, 2004)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	vas^{Δ617.T:Avic\GFP-EGFP} vas^Δ617 (Johnstone and Lasko, 2004, Liu et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Pek and Kai, 2011, Curr. Biol. 21(1): 39--44 A role for vasa in regulating mitotic chromosome condensation in Drosophila. [FBrf0212718] Liu et al., 2009, Genes Dev. 23(23): 2742--2752 Vasa promotes Drosophila germline stem cell differentiation by activating mei-P26 translation by directly interacting with a (U)-rich motif in its 3' UTR. [FBrf0209427] Johnstone and Lasko, 2004, Development 131(17): 4167--4178 Interaction with eIF5B is essential for Vasa function during development. [FBrf0180140]

Allele Dmel\vasΔ617.T:Avic\GFP-EGFP

Allele Dmel\vas^{Δ617.T:Avic\GFP-EGFP}