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General Information
Symbol
Dmel\sdΔ88-159.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0178072
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UASsdΔ88-159
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A cDNA fragment corresponding to sd with an internal deletion, removing amino acids 88-159, is expressed under the control of UASt regulatory sequences. This deletion removes the sd TEA domain.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of sdΔ88-159.Scer\UAS in the wing disc (under the control of Scer\GAL4sd-SG29.1) produces elongated pupae and adults and causes loss of the adult wing.

Expression of sdΔ88-159.Scer\UAS in muscle cells under the control of Scer\GAL4Mef2.PR results in 78% pupal lethality. Larvae exhibit obvious gaps between the dorsal acute (DA)1 muscles are larger than in wild-type, suggesting the elongated body type is caused by muscle defects.

Expression of sdΔ88-159.Scer\UAS at early embryo developmental stages (7-11) under the control of Scer\GAL4twi.PG does not lead to elongated adults and significant lethality.

Expression of sdΔ88-159.Scer\UAS, driven by Scer\GAL4vg.boundary, leads to an enhancement of the wing phenotypes seen in sdETX4 and sd58d mutants. Overexpression of sdΔ88-159.Scer\UAS driven by Scer\GAL4vg.boundary leads to a defective wing phenotype in wild-type flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of both vgScer\UAS.T:Ivir\HA1 and sdΔ88-159.Scer\UAS in developing muscles under the control of Scer\GAL4Mef2.PR results in fewer ectopic muscle attachments (24.5% compared with 81.8% when vgScer\UAS.T:Ivir\HA1 is expressed alone).

Ectopic expression of vg2.Scer\UAS within the lateral transverse muscles with sdΔ88-159.Scer\UAS (with both under the control of Scer\GAL4C23 leads to partial suppression of the vg2.Scer\UAS-induced muscle phenotype.

Blocking vg function through expression of sdΔ88-159.Scer\UAS in ventral longitudinal muscle cells (under the control of Scer\GAL4Mef2.PR) that abnormally migrate along the midline owing to a sli2 mutant background, leads to fewer and smaller muscle-muscle adhesions.

Xenogenetic Interactions
Statement
Reference

Mesodermal expression of constitutively active btl::EgfrScer\UAS.T:λ\cI-DD in sli2 mutants (under the control of Scer\GAL4Mef2.PR) produces many small adhesion sites between midline-crossing ventral longitudinal muscles. This ectopic attachment phenotype is vg-specific as interfering with vg function through coexpression of sdΔ88-159.Scer\UAS results in fewer of these adhesion sites.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
sdΔ88-159.Scer\UAS
sdΔ88-159.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)