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General Information
Symbol
Dmel\msnDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0178813
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-DN-msn
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt sequences drive expression of msn in which the middle proline rich region (amino acids 330-768) has been deleted.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of msnDN.Scer\UAS under the control of Scer\GAL4twi.PG results in delayed or defective ventral furrow formation in a proportion of embryos.

Expression of msnDN.Scer\UAS in the whole epidermis of embryos, driven by Scer\GAL4e22c, results in breaks in the localization of actin and myosin at the epithelial margin. These gaps correlate with reduced elongation and leading edge constriction of the affected cells. The same phenotype is seen when msnDN.Scer\UAS is expressed in the marginal cells of the epidermis using Scer\GAL4LE.

Expression of msnDN.Scer\UAS in the amnioserosa cells of embryos, driven by Scer\GAL4c381, results in head problems in less than 10% of embryos, which vary from an anterior hole to dorsal-anterior holes.

When msnDN.Scer\UAS is expressed in the developing eye of msn03349/+ animals a R-cell nuclear migration phenotype is seen in 47% of mutant eye discs. Only 5% of msn03349/+ eye discs show this phenotype on its own.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, enhanceable by Df(2L)TW119

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, enhanceable by Lis-1k13209

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, enhanceable by BicDr5/BicDr5

NOT Enhanced by
Statement
Reference

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, non-enhanceable by Cdc423

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, non-enhanceable by Pak6

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, non-enhanceable by bsk2

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, non-enhanceable by capuM732

Scer\GAL4unspecified, msnDN.UAS has photoreceptor cell | precursor & nucleus phenotype, non-enhanceable by klarmarb-BX5

NOT suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The defects in ventral furrow formation seen in embryos expressing msnDN.Scer\UAS under the control of Scer\GAL4twi.PG are not suppressed in embryos derived from bskunspecified female germline clones.

42% of animals expressing msnDN.Scer\UAS in the developing eye, combined with BicDr5/+ exhibit a R-cell nuclear migration phenotype. 37% of animals expressing msnDN.Scer\UAS in the developing eye, combined with Df(2L)TW119/+ exhibit a R-cell nuclear migration phenotype. 7% of animals expressing msnDN.Scer\UAS in the developing eye, combined with bsk2/+ exhibit a R-cell nuclear migration phenotype. 0% of animals expressing msnDN.Scer\UAS in the developing eye, combined with capuM732/+ exhibit a R-cell nuclear migration phenotype. 0% of animals expressing msnDN.Scer\UAS in the developing eye, combined with Cdc423/+ exhibit a R-cell nuclear migration phenotype. 21% of animals expressing msnDN.Scer\UAS in the developing eye, combined with Lis-1k13209/+ exhibit a R-cell nuclear migration phenotype. 0% of animals expressing msnDN.Scer\UAS in the developing eye, combined with klarmarb-BX5/+ exhibit a R-cell nuclear migration phenotype. 0% of animals expressing msnDN.Scer\UAS in the developing eye, combined with Pak6/+ exhibit a R-cell nuclear migration phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to rescue
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
msnDN.Scer\UAS
msnDN.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)