|Feature type||allele||Associated gene||Dmel\mats|
|Mutagen||transposable element activity|
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Controlled Vocabulary Terms
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
Occasional mats[roo]/+ mutant flies are observed to develop tumors. Some flies expressing mats[2236.T:Avic\GFP] in a homozygous mats[roo] mutant background exhibit small tumors. Some flies expressing mats[2236.T:Avic\GFP] in a mats[roo]/mats[e235] mutant background exhibit small tumors.
When matsroo mutant clones are made, large tumors can be induced in many organs, including the head, notum, eye wing, antenna and halteres. The tumor cells form unpatterned tissues with many folds on the surface, the mutant cells clearly overproliferating. Cell sized is not significantly different from wild-type. When clones are made in the larval eye discs, photoreceptors and cone cells appear to be specified normally, however they fail to fully differentiate to generate ommatidia in adults.
|Phenotype Manifest In|
matsroo allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). matsroo does not prevent loss of Df(1)su(s)R194/+ clones in the wing disc.
|Complementation & Rescue Data|
|Partially rescued by|
|Not rescued by|
|Fails to rescue|
mats[e17] fails to complement the tissue overgrowth seen in mats[roo]. mats[e17] complements the lethality associated with mats[roo]. Expression of mats[2236.T:Avic\GFP] partially rescues the second instar larval lethality seen in homozygous mats[roo] mutant flies. 60% of flies survive to the pupal stage and 25% reach the adult stage. Expression of mats[2236.T:Avic\GFP] partially rescues the second instar larval lethality seen in homozygous mats[roo]/mats[e235] mutant flies. Many flies survive to the pupal stage with some reaching the adult stage. mats[Δ5.T:Avic\GFP] is unable to rescue the second instar larval lethality seen in homozygous mats[roo] mutant flies. mats[Δ3.T:Avic\GFP] is unable to rescue the second instar larval lethality seen in homozygous mats[roo] mutant flies.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 3 )|