Allele Dmel\mats^roo

General Information
Symbol	Dmel\mats^roo	Species	D. melanogaster
Name		FlyBase ID	FBal0178932
Feature type	allele	Associated gene	Dmel\mats

Allele class
Mutagen	transposable element activity
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms dominant adult stage
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	transposable element activity (Lai et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The roo sequence is inserted behind codon 84 to cause a premature termination. (Lai et al., 2005)
Caused by insertion	roo{}mats^roo (Lai et al., 2005, Yang et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive \| second instar larval stage (Lai et al., 2005) lethal \| second instar larval stage (Yang et al., 2008) lethal \| second instar larval stage (with mats^e235) (Yang et al., 2008) tumorigenic \| adult stage (with mats^{2236.T:Avic\GFP}) (Yang et al., 2008) tumorigenic \| adult stage (with mats^e235), with mats^{2236.T:Avic\GFP} (Yang et al., 2008, Yang et al., 2008) tumorigenic \| adult stage \| dominant (Yang et al., 2008) tumorigenic \| somatic clone (Lai et al., 2005)
Phenotype Manifest In

Detailed Description
	Statement Reference Occasional mats[roo]/+ mutant flies are observed to develop tumors. Some flies expressing mats[2236.T:Avic\GFP] in a homozygous mats[roo] mutant background exhibit small tumors. Some flies expressing mats[2236.T:Avic\GFP] in a mats[roo]/mats[e235] mutant background exhibit small tumors. (Yang et al., 2008) When mats^roo mutant clones are made, large tumors can be induced in many organs, including the head, notum, eye wing, antenna and halteres. The tumor cells form unpatterned tissues with many folds on the surface, the mutant cells clearly overproliferating. Cell sized is not significantly different from wild-type. When clones are made in the larval eye discs, photoreceptors and cone cells appear to be specified normally, however they fail to fully differentiate to generate ommatidia in adults. (Lai et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference mats^roo has tumorigenic \| somatic clone phenotype, suppressible by Hsap\MOB1A^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^αTub84B.PL (Lai et al., 2005)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference mats^roo allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). mats^roo does not prevent loss of Df(1)su(s)R194/+ clones in the wing disc. (Tyler et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	mats^roo is rescued by mats^Scer\UAS.cLa/Scer\GAL4^arm.PS (Lai et al., 2005)
Partially rescued by	mats^roo/mats^e235 is partially rescued by mats^{2236.T:Avic\GFP} (Yang et al., 2008) mats^roo is partially rescued by mats^{2236.T:Avic\GFP} (Yang et al., 2008) mats^roo is partially rescued by mats^Scer\UAS.cLa/Scer\GAL4^αTub84B.PL (Lai et al., 2005)
Not rescued by	mats^roo is not rescued by mats^e235 (Lai et al., 2005) mats^roo is not rescued by mats^{Δ3.T:Avic\GFP} (Yang et al., 2008) mats^roo is not rescued by mats^{Δ5.T:Avic\GFP} (Yang et al., 2008)
Fails to rescue	mats^roo fails to rescue mats^e235 (Lai et al., 2005)
Comments	mats[e17] fails to complement the tissue overgrowth seen in mats[roo]. mats[e17] complements the lethality associated with mats[roo]. Expression of mats[2236.T:Avic\GFP] partially rescues the second instar larval lethality seen in homozygous mats[roo] mutant flies. 60% of flies survive to the pupal stage and 25% reach the adult stage. Expression of mats[2236.T:Avic\GFP] partially rescues the second instar larval lethality seen in homozygous mats[roo]/mats[e235] mutant flies. Many flies survive to the pupal stage with some reaching the adult stage. mats[Δ5.T:Avic\GFP] is unable to rescue the second instar larval lethality seen in homozygous mats[roo] mutant flies. mats[Δ3.T:Avic\GFP] is unable to rescue the second instar larval lethality seen in homozygous mats[roo] mutant flies. (Yang et al., 2008)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	mats^roo (Tyler et al., 2007, Yang et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Yang et al., 2008, FEBS Lett. 582(12): 1766--1770 Both upstream and downstream intergenic regions are critical for the mob as tumor suppressor gene activity in Drosophila. [FBrf0204945] Tyler et al., 2007, Genetics 175(2): 643--657 Genes affecting cell competition in Drosophila. [FBrf0192304] Lai et al., 2005, Cell 120(5): 675--685 Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. [FBrf0183777]

Allele Dmel\matsroo

Allele Dmel\mats^roo