FlyBase Allele Report: Dmel\mats[e235]

General Information

Symbol

Dmel\mats^e235

Species

D. melanogaster

Name

FlyBase ID

FBal0178933

Feature type

allele

Associated gene

Dmel\mats

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Lai et al., 2005)

Progenitor genotype

EP3303^EP3303

(Lai et al., 2005)

Caused by aberration

Df(3R)mats^e325

Cytology

Description

Imprecise excision of the P{EP}EP3303^EP3303 insertion has created a deletion that removes the second and third exons of mats.

(Lai et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage (with mats^A33)

(Liu et al., 2016)

abnormal mitotic cell cycle | somatic clone

(Lai et al., 2005)

lethal

(Yang et al., 2008)

lethal (with mats^e03077)

(He et al., 2005)

lethal - all die before end of second instar larval stage (with mats^roo)

(Yang et al., 2008)

lethal - all die before end of second instar larval stage | recessive

(Lai et al., 2005)

neoplasia | adult stage (with mats^e17)

(Yang et al., 2008)

neoplasia | adult stage (with mats^roo), with mats^2236.GFP

(Yang et al., 2008)

neoplasia | adult stage | dominant

(Yang et al., 2008)

neoplasia | somatic clone

(Lai et al., 2005)

some die during second instar larval stage (with mats^roo)

(Yang et al., 2008)

some die during second instar larval stage | recessive

(Lai et al., 2005)

viable (with mats^A33)

(Liu et al., 2016)

Phenotype Manifest In

anepisternum (with mats^e17)

(Yang et al., 2008)

postpronotum (with mats^e17)

(Yang et al., 2008)

Detailed Description

Statement

Reference

mats^A33/mats^e235 adult flies have significantly reduced survival in response to Gram-positive bacteria (Staphylococcus aureus) but not Gram-negative bacteria (Erwinia carotovora carotovora 15), compared to controls.

(Liu et al., 2016)

Cells in homozygous clones in the wing disc accumulate F-actin near the apical surface.

(Fernández et al., 2011)

Half of mats^e17/mats^e235 mutant flies show a tissue overgrowth phenotype in the humerus and mesopleuron.

Some flies expressing mats^{2236.T:Avic\GFP} in a mats^roo/mats^e235 mutant background exhibit small tumors.

Occasional mats^e235/+ mutant flies are observed to develop tumors.

(Yang et al., 2008)

Mutant eye discs (generated using the eyFLP-cell lethal system) do not show defects in epithelial organisation or neuronal differentiation.

(Menut et al., 2007)

When mats^e325 mutant clones are made in the eye, more mitoses are seen in clones compared to wild-type cells, and mitoses can even occur in the morphogenetic furrow. Excess mitoses are also found in clones located in the posterior margin.

(Lai et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

mats^e235 has neoplasia | somatic clone phenotype, non-enhanceable by wts^x1

(Lai et al., 2005)

NOT suppressed by

Statement

Reference

mats^e235 has neoplasia | somatic clone phenotype, non-suppressible by wts^x1

(Lai et al., 2005)

Enhancer of

Statement

Reference

mats^e235/mats[+] is an enhancer of visible phenotype of Scer\GAL4^ptc-559.1, trc^T453A.UAS.L

(He et al., 2005)

Suppressor of

Statement

Reference

mats^e235 is a suppressor of increased cell death phenotype of hid^GMR.PG

(Lai et al., 2005)

Other

Statement

Reference

fry²/fry[+], mats^e235, trc¹/trc[+] has visible | dominant phenotype

(He et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

mats^e235/mats[+] is an enhancer of wing hair | increased number phenotype of Scer\GAL4^ptc-559.1, trc^T453A.UAS.L

(He et al., 2005)

Suppressor of

Statement

Reference

mats^e235 is a suppressor of eye phenotype of hid^GMR.PG

(Lai et al., 2005)

mats^e235 is a suppressor of ommatidium phenotype of wts^GMR.PT

(Lai et al., 2005)

mats^e235 is a suppressor of eye phenotype of wts^GMR.PT

(Lai et al., 2005)

Other

Statement

Reference

fry²/fry[+], mats^e235, trc¹/trc[+] has wing hair | increased number phenotype

(He et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

mats^e235 allows recovery of Df(1)su(s)R194/+ clones in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36^+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals).

(Tyler et al., 2007)

The multiple wing hair phenotype that is caused by expression of trc^{T453A.Scer\UAS} under the control of Scer\GAL4^ptc-559.1 is dominantly enhanced by mats^e235.

fry² trc¹ mats^e235 triple heterozygotes have a weak multiple wing hair phenotype in 48% of wings.

(He et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mats^e03077

(He et al., 2005)

mats^roo

(Lai et al., 2005)

Rescued by

mats^e235 is rescued by mats^UAS.cLa/Scer\GAL4^arm.PS

(Lai et al., 2005)

Partially rescued by

mats^roo/mats^e235 is partially rescued by mats^2236.GFP

(Yang et al., 2008)

Comments

mats^e17 fails to complement the tissue overgrowth seen in mats^e235.

mats^e17 complements the lethality associated with mats^e235.

Expression of mats^{2236.T:Avic\GFP} partially rescues the second instar larval lethality seen in mats^roo/mats^e235 mutant flies. Many flies survive to the pupal stage and some reach the adult stage.

(Yang et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mats^e235

(Kulaberoglu et al., 2017, Liu et al., 2016, Fernández et al., 2011, Ho et al., 2010, Oh and Irvine, 2008, Yang et al., 2008, Menut et al., 2007, Tyler et al., 2007, Cho et al., 2006, He et al., 2005)

mats^e325

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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