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General Information
Symbol
Dmel\hpodsRNA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0179448
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS sequences are cloned upstream of the C-terminal 1138-2514 nucleotides of hpo used to generate dsRNA within the cell.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of hpodsRNA.Scer\UAS under the control of Scer\GAL4sd-SG29.1 results in an expansion (by 55%) of the distal hinge domain of the wing disc.
Expression of hpodsRNA.Scer\UAS under the control of Scer\GAL4en-e16E results in wing overgrowth.
Pupal eye clones of cells expressing hpodsRNA.Scer\UAS driven by Scer\GAL4αTub84B.PL exhibit increased clonal area as well as overproliferation of interommatidial cells.
hpodsRNA.Scer\UAS expression in somatic clones induces an increase in tissue and organ size, leading, for example, to oversized halteres, or to an overgrowth of imaginal discs. Photoreceptor differentiation in the third instar larval eye imaginal disc is unaffected by hpodsRNA.Scer\UAS induction, however, third instar eye imaginal discs containing large flp-out hpodsRNA.Scer\UAS clones are enlarged compared to wild-type. Cells in larval eye imaginal disc hpodsRNA.Scer\UAS clones fail to arrest in the morphogenetic furrow and, after the second mitotic wave, undergo additional rounds of division.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressor of
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference
Tao50 enhances the increase in wing size seen when hpodsRNA.Scer\UAS is expressed under the control of Scer\GAL4en-e16E.
Homozygous mutant clones of Df(1)djubI also expressing wtsGD1563 driven by Scer\GAL4αTub84B.PL display a Df(1)djubI-like phenotype of decreased clonal area.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
hpodsRNA.Scer\UAS
hpodsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (7)