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General Information
Symbol
Dmel\vibZ3934
Species
D. melanogaster
Name
FlyBase ID
FBal0179652
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Sequencing of the vibZ3934 allele does not reveal a mutation in the coding region, suggesting a mutation in the promoter region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

contractile ring & meiotic telophase I | male

contractile ring & meiotic telophase I | male (with Df(3R)Dl-BX12)

contractile ring & meiotic telophase II | male

contractile ring & meiotic telophase II | male (with Df(3R)Dl-BX12)

spermatid & nucleus | supernumerary

spermatid & nucleus | supernumerary (with Df(3R)Dl-BX12)

spindle & meiotic telophase I | male

spindle & meiotic telophase I | male (with Df(3R)Dl-BX12)

spindle & meiotic telophase II | male

spindle & meiotic telophase II | male (with Df(3R)Dl-BX12)

Detailed Description
Statement
Reference

gioZ3934 mutants are defective in spermatocyte cytokinesis and display large and incompletely constricted actomyosin rings.

Flies homozygous for vibZ3934 show frequent multinucleate spermatids.

Larval brains of vibZ3934 mutants exhibit frequent polyploid cells but have normal frequences of anaphases, consistent with a defect in neuroblast cytokinesis.

vibZ3934 homozygotes and vibZ3934/Df(3R)Dl-BX12 mutants exhibit defective telophase, with incompletely constricted contractile rings and central spindles that are either normal or less dense than their wild-type counterparts.

A significant proportion of gioZ3934 mutant spermatids have one large nebenkern with two nuclei of normal size, indicating failure of cytokinesis in one of the meiotic divisions. Some spermatids have four nuclei and a large nebenkern, indicating a cytokinetic failure in both meiotic divisions. A small proportion of spermatids have three nuclei, which may be due to failure of cytokinesis in the first meiotic division, followed by budding off of only one daughter cell in the second meiotic division. The spermatids of gioZ3934/Df(3R)Dl-BX12 mutants show the two and four nuclei phenotypes. During early telophase of gioZ3934 spermatocytes, there is an actin ring of normal appearance and and a normal central spindle. However, as telophase progresses the actin ring often fails to fully constrict and in late telophases where there is a high degree of constriction, there is a greater amount of F-actin at the ring. In a small proportion of late telophase figures, the central spindle is also defective. gioZ3934/Df(3R)Dl-BX12 mutants show the same phenotype.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)